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573080 STAT1 Enhancer, 2-NP - CAS 65182-56-1 - Calbiochem

573080
  
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
65182-56-1C₁₄H₁₀N₂O
Description
Overview

This product has been discontinued.



A cell-permeable naphthyridinyl-phenolic compound that selectively enhances cytokine-induced STAT1 transcription activity, but not that of STAT3 or NF-κB. Shown to prolong INF-γ-induced tyrosine phosphorylation of STAT1 in NIH3T3 cells and accentuate the STAT1-dependent growth inhibition in MCF-7 and 2fTGH cancer cells.

Catalogue Number573080
Brand Family Calbiochem®
Synonyms2-NP, 2-(1,8-Naphthyridin-2-yl)phenol
References
ReferencesLynch, R. A., et al. 2007. Cancer Res. 67, 1254.
Product Information
CAS number65182-56-1
ATP CompetitiveN
FormOrange solid
Hill FormulaC₁₄H₁₀N₂O
Chemical formulaC₁₄H₁₀N₂O
ReversibleN
Structure formula ImageStructure formula Image
Applications
Biological Information
Primary TargetSelectively enhances cytokine-induced STAT1 transcription activity
Purity≥98% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Regulatory Review
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
573080 0

Documentation

STAT1 Enhancer, 2-NP - CAS 65182-56-1 - Calbiochem MSDS

Title

Safety Data Sheet (SDS) 

References

Reference overview
Lynch, R. A., et al. 2007. Cancer Res. 67, 1254.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision19-April-2011 RFH
Synonyms2-NP, 2-(1,8-Naphthyridin-2-yl)phenol
DescriptionA cell-permeable naphthyridinyl-phenolic compound that selectively enhances cytokine-induced STAT1 transcription activity, but not that of STAT3 or NF-κB. Shown to prolong INF-γ-induced tyrosine phosphorylation of STAT1 in NIH3T3 cells and accentuate the STAT1-dependent growth inhibition in MCF-7 and 2fTGH cancer cells.
FormOrange solid
Intert gas (Yes/No) Packaged under inert gas
CAS number65182-56-1
Chemical formulaC₁₄H₁₀N₂O
Structure formulaStructure formula
Purity≥98% by HPLC
SolubilityDMSO (10 mg/ml)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity Regulatory Review
ReferencesLynch, R. A., et al. 2007. Cancer Res. 67, 1254.