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508512 SNX-482 - CAS 203460-30-4 - Calbiochem

A peptidyl toxin from venom of African tarantula, Hysterocrates gigas that acts as a high affinity, reversible blocker of Cav2.3 (α1E, R-type) channels (IC₅₀ = 15-30 nM).

SNX-482 - CAS 203460-30-4 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Primary Target: Cav2.3 channels
508512
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
203460-30-4C₁₉₂H₂₇₄N₅₂O₆₀S₇

Products

Catalogue NumberPackaging Qty/Pack
5.08512.0001 Sklená flaša 10 μg
Description
OverviewA peptidyl toxin present in the venom of African tarantula, Hysterocrates gigas that acts as a high affinity, reversible blocker of Cav2.3 (α1E, R-type) channels (IC50 = 15-30 nM). The inhibition appears to be voltage-dependent. At lower concentrations it is also shown to block native R-type Ca2+ current in rat neurohypophyseal nerve terminals, however, these effects are not observed at higher concentrations. Does not affect Na+ or K+ currents in several cultured cell types (~ 500 nM).
Catalogue Number508512
Brand Family Calbiochem®
References
ReferencesAbitbol, K. et al. 2012. J. Physiol. 590, 2977.
Newcomb, R., et al., 1998. Biochemistry. 37, 15353.
Product Information
CAS number203460-30-4
FormWhite solid
Hill FormulaC₁₉₂H₂₇₄N₅₂O₆₀S₇
Chemical formulaC₁₉₂H₂₇₄N₅₂O₆₀S₇
Quality LevelMQ100
Applications
Biological Information
Primary TargetCav2.3 channels
Primary Target IC<sub>50</sub>15-30 nM
Purity≥98% by HPLC
Physicochemical Information
Peptide SequenceGVDKAGCRYMFGGCSVNDDCCPRLGCHSLF→SYCAWDLTFSD (difulfid bond: 7-21, 14-26, 20-33)
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze(-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
5.08512.0001 04055977262049

Documentation

SNX-482 - CAS 203460-30-4 - Calbiochem MSDS

Title

Safety Data Sheet (SDS) 

References

Reference overview
Abitbol, K. et al. 2012. J. Physiol. 590, 2977.
Newcomb, R., et al., 1998. Biochemistry. 37, 15353.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision31-January-2014 JSW
DescriptionA peptidyl toxin present in the venom of African tarantula, Hysterocrates gigas that acts as a high affinity, reversible blocker of Cav2.3 (α1E, R-type) channels (IC50 = 15-30 nM). The inhibition appears to be voltage-dependent. At lower concentrations it is also shown to block native R-type Ca2+ current in rat neurohypophyseal nerve terminals, however, these effects are not observed at higher concentrations. Does not affect Na+ or K+ currents in several cultured cell types (~ 500 nM).
FormWhite solid
CAS number203460-30-4
Chemical formulaC₁₉₂H₂₇₄N₅₂O₆₀S₇
Peptide SequenceGVDKAGCRYMFGGCSVNDDCCPRLGCHSLF→SYCAWDLTFSD (difulfid bond: 7-21, 14-26, 20-33)
Purity≥98% by HPLC
Storage Protect from light
-20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze(-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesAbitbol, K. et al. 2012. J. Physiol. 590, 2977.
Newcomb, R., et al., 1998. Biochemistry. 37, 15353.