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573117 SMC Proliferation Inhibitor-2w

The SMC Proliferation Inhibitor-2w, also referenced under CAS 343783-87-9, inhibits the proliferation of human coronary artery smooth muscle cells.

SMC Proliferation Inhibitor-2w MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: N-(3ʹ,4ʹ,5ʹ,-Trimethoxybenzoyl)-(3,4-dimethoxy)ethylanthranilate

573117
  
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
343783-87-9C₂₁H₂₅NO₈
Description
Overview

This product has been discontinued.





A diaryl amide analog that exhibits about 15 fold greater selectivity in inhibiting the proliferation of human coronary artery smooth muscle cells (IC50 = 310 nM) over the endothelial cells (IC50 = 4.6 µM). Exhibits over 80-fold greater potency than Tranilast (Cat. No. 616400).
Catalogue Number573117
Brand Family Calbiochem®
SynonymsN-(3ʹ,4ʹ,5ʹ,-Trimethoxybenzoyl)-(3,4-dimethoxy)ethylanthranilate
References
ReferencesOgita, H., et al. 2001. Bioorg. Med. Chem. Lett. 11, 549.
Product Information
CAS number343783-87-9
FormOff-white solid
Hill FormulaC₂₁H₂₅NO₈
Chemical formulaC₂₁H₂₅NO₈
Structure formula ImageStructure formula Image
Applications
Biological Information
Purity≥95% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
R PhraseR: 20/21/22

Harmful by inhalation, in contact with skin and if swallowed.
S PhraseS: 36

Wear suitable protective clothing.
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Harmful
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
573117 0

Documentation

SMC Proliferation Inhibitor-2w MSDS

Title

Safety Data Sheet (SDS) 

SMC Proliferation Inhibitor-2w Certificates of Analysis

TitleLot Number
573117

References

Reference overview
Ogita, H., et al. 2001. Bioorg. Med. Chem. Lett. 11, 549.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision19-April-2011 RFH
SynonymsN-(3ʹ,4ʹ,5ʹ,-Trimethoxybenzoyl)-(3,4-dimethoxy)ethylanthranilate
DescriptionA diarylamide derivative that exhibits about 15-fold greater selectivity in inhibiting the proliferation of human coronary artery smooth muscle cells (SMCs) (IC50 = 310 nM) compared to endothelial cells (IC50 = 4.6 µM). Exhibits ~80-fold greater potency than Tranilast (Cat. No. 616400) in inhibition of PDGF-induced proliferation of SMCs.
FormOff-white solid
Intert gas (Yes/No) Packaged under inert gas
CAS number343783-87-9
Chemical formulaC₂₁H₂₅NO₈
Structure formulaStructure formula
Purity≥95% by HPLC
SolubilityDMSO (5 mg/ml)
Storage Protect from light
-20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity Harmful
ReferencesOgita, H., et al. 2001. Bioorg. Med. Chem. Lett. 11, 549.