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530236 SKP2 E3 Ligase Inhibitor IV - CAS 634908-46-6 - Calbiochem

530236
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Overview

Key Spec Table

CAS #Empirical Formula
634908-46-6C₂₆H₃₈N₂O • 2HCl

Products

Catalogue NumberPackaging Qty/Pack
5.30236.0001 Sklená flaša 10 mg
Description
OverviewA cell-permeable dimethylanilinomethylamine compound that inhibits SKP2-dependent p27Kip1 ubiquitination (10 to 30 µM; 16 h; in MM1.S myeloma and HeLa cultures) by preventing the incorporation of SKP2 into the Skp1-cullin1-F-box/SCF complex. Selectively induces the accumulation SCFSKP2 substrates in multiple myeloma RPMI 8226 cells without affecting cellular levels of Fbw7 or β-TrCP substrate (c-Jun and β-catenin, respectively) seen with proteasome inhibition by Bortezomib (Cat. No. 504314) treatment. Shown to exhibit cancer-selective cytotoxicity against primary CD138+ malignant cells over CD138- nonneoplastic blood cells from MM patient blood (viability in 24 h with/without 5 µM drug treatment = 1.38%/66.4% for CD138+ vs. 81.3%/94% CD138-).
Catalogue Number530236
Brand Family Calbiochem®
SynonymsCRL1SKP2 Inhibitor IV, p21/Cip1/Waf1 Activator IV, p27/Kip1 Activator IV, S-phase Kinase-associated Protein 2 Inhibitor IV; SCFSKP2 Inhibitor IV, (±)-4-((3-(2,2-Dimethyltetrahydro-2H-pyran-4-yl)-4-phenylbutylamino)methyl)-N,N-dimethylaniline, 2HCl
References
ReferencesChen, Q., et al. 2008. Blood 111, 4690.
Product Information
CAS number634908-46-6
FormWhite solid
Hill FormulaC₂₆H₃₈N₂O • 2HCl
Chemical formulaC₂₆H₃₈N₂O • 2HCl
ReversibleY
Quality LevelMQ100
Biological Information
Primary TargetSkp1/Skp2 interaction
Purity≥95% by HPLC
Physicochemical Information
Cell permeableY
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Global Trade Item Number
Catalogue Number GTIN
5.30236.0001 04055977261318