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508318 SHIP2 Inhibitor II, CPDA - CAS 1415834-63-7 - Calbiochem

SHIP2 Inhibitor II, CPDA - CAS 1415834-63-7 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Primary Target: SHIP2
508318
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
1415834-63-7C₂₀H₁₅ClF₂N₂O₂

Products

Catalogue NumberPackaging Qty/Pack
5.08318.0001 Sklená flaša 10 mg
Description
OverviewA cell-permeable aminopyridine acetamide based compound that acts as an inhibitor of SH2 domain-containing inositol 5′-phosphatase 2 (SHIP2) that can overcome insulin resistance in 3T3-L1 adipocytes. Enhances insulin-stimulated Akt phosphorylation (Thr308) in TNFa-treated 3T3-L1 adipocytes (~10 µM) and in primary cultured neurons from rat cerebral cortex. Improves glucose tolerance in db/db mice (~300 mg/kg b.i.d) without affecting their fasting glucose levels. Also reduces the expression levels of glucose-6-phosphatase and phosphoenolpyruvate carboxykinase.
Catalogue Number508318
Brand Family Calbiochem®
References
ReferencesIchihara, Y., et al, 2013. Eur. J. Med. Chem. 62, 649.
Product Information
CAS number1415834-63-7
FormWhite solid
Hill FormulaC₂₀H₁₅ClF₂N₂O₂
Chemical formulaC₂₀H₁₅ClF₂N₂O₂
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetSHIP2
Purity≥98% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
5.08318.0001 04055977261868

Documentation

SHIP2 Inhibitor II, CPDA - CAS 1415834-63-7 - Calbiochem MSDS

Title

Safety Data Sheet (SDS) 

References

Reference overview
Ichihara, Y., et al, 2013. Eur. J. Med. Chem. 62, 649.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision13-December-2013 JSW
DescriptionA cell-permeable aminopyridine acetamide based compound that acts as an inhibitor of SH2 domain-containing inositol 5′-phosphatase 2 (SHIP2) that can overcome insulin resistance in 3T3-L1 adipocytes. Enhances insulin-stimulated Akt phosphorylation (Thr308) in TNFa-treated 3T3-L1 adipocytes (~10 µM) and in primary cultured neurons from rat cerebral cortex. Improves glucose tolerance in db/db mice (~300 mg/kg b.i.d) without affecting their fasting glucose levels. Also reduces the expression levels of glucose-6-phosphatase and phosphoenolpyruvate carboxykinase.
FormWhite solid
Intert gas (Yes/No) Packaged under inert gas
CAS number1415834-63-7
Chemical formulaC₂₀H₁₅ClF₂N₂O₂
Structure formulaStructure formula
Purity≥98% by HPLC
SolubilityDMSO (100 mg/ml)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesIchihara, Y., et al, 2013. Eur. J. Med. Chem. 62, 649.