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505723 SCH 23390 Hydrochloride - CAS 125941-87-9 - Calbiochem

SCH 23390 Hydrochloride - CAS 125941-87-9 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Dopamine Receptor D1/D5 Antagonist, SCH 23390, (R)-(+)-7-Chloro-8-hydroxy-3-methyl­-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine Hydrochloride, SCH23390, SCH-23390

Primary Target: D1 and D5
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
125941-87-9C₁₇H₁₈ClNO•HCl
Description
OverviewA highly potent and selective dopamine D1-like receptor antagonist with a Ki of 0.2 and 0.3 nM for the D1 and D5 dopamine receptor subtypes, respectively. Also an agonist at 5-HT1C and 5-HT2C receptors in vitro (Ki values are 6.3 nM and 9.3 nM respectively).
Catalogue Number505723
Brand Family Calbiochem®
SynonymsDopamine Receptor D1/D5 Antagonist, SCH 23390, (R)-(+)-7-Chloro-8-hydroxy-3-methyl­-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine Hydrochloride, SCH23390, SCH-23390
References
ReferencesSplinter, M. Y. 2007. Ann. Pharmacother. 41, 285.
Pfeiffer, R. F. 2002. Drugs Aging. 19, 561.
Product Information
CAS number125941-87-9
FormOff-white solid
Hill FormulaC₁₇H₁₈ClNO•HCl
Chemical formulaC₁₇H₁₈ClNO•HCl
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetD1 and D5
Primary Target K<sub>i</sub>0.2 nM
Purity≥99% by Chiral HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
505723 0

Documentation

SCH 23390 Hydrochloride - CAS 125941-87-9 - Calbiochem MSDS

Title

Safety Data Sheet (SDS) 

References

Reference overview
Splinter, M. Y. 2007. Ann. Pharmacother. 41, 285.
Pfeiffer, R. F. 2002. Drugs Aging. 19, 561.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision30-August-2013 JSW
SynonymsDopamine Receptor D1/D5 Antagonist, SCH 23390, (R)-(+)-7-Chloro-8-hydroxy-3-methyl­-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine Hydrochloride, SCH23390, SCH-23390
DescriptionA highly potent and selective dopamine D1-like receptor antagonist with a Ki of 0.2 and 0.3 nM for the D1 and D5 dopamine receptor subtypes, respectively. Also an agonist at 5-HT1C and 5-HT2C receptors in vitro (Ki values are 6.3 nM and 9.3 nM respectively).
FormOff-white solid
CAS number125941-87-9
Chemical formulaC₁₇H₁₈ClNO•HCl
Structure formulaStructure formula
Purity≥99% by Chiral HPLC
SolubilityH₂O (100 mM)
Storage Protect from light
-20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesSplinter, M. Y. 2007. Ann. Pharmacother. 41, 285.
Pfeiffer, R. F. 2002. Drugs Aging. 19, 561.