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506417 SB 242084 Hydrochloride - CAS 1260505-34-7 - Calbiochem

SB 242084 Hydrochloride - CAS 1260505-34-7 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 5-HT2C receptor antagonist, SB 242084 Hydrochloride, SB-242084 Hydrochloride, SB242084 Hydrochloride

Primary Target: 5-HT2C
506417
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
1260505-34-7C₂₁H₁₉ClN₄O₂·HCl

Products

Catalogue NumberPackaging Qty/Pack
5.06417.0001 Sklená flaša 10 mg
Description
OverviewA selective, brain-penetrant 5-HT2C receptor antagonist (pKi 8.2-9.0 ), with some effects on the 5-HT2B receptor (pKi 6.8-7.0) and 5-HT2A receptor (pKi 6.1-6.8). SB 242084 has been shown to increase the effectiveness of the selective serotonin reuptake inhibitor (SSRI) class of antidepressants, and may also reduce their side effects. In animal studies, SB-242,084 produced stimulant-type activity and reinforcing effects, somewhat similar to but much weaker than cocaine or amphetamines. In vivo (ocular) IC50 values reported at 2.08 µM.
Catalogue Number506417
Brand Family Calbiochem®
Synonyms5-HT2C receptor antagonist, SB 242084 Hydrochloride, SB-242084 Hydrochloride, SB242084 Hydrochloride
References
ReferencesManvich, D. F., et al. 2012. J Pharmacol. Exp. Ther. 342, 761.
Burghardt, N. S., et al. 2007. Biol Psychiatry 62, 1111.
Sharif, N. A., et al. 2007. J. Ocul. Pharmacol. Ther. 23, 1.
Knight A. R., et al. 2004. Naunyn Schmiedebergs Arch. Pharmacol. 370, 114.
Kennett G.A., et al. 1997. Neuropharmacol. 36, 609.
Product Information
CAS number1260505-34-7
FormOff-white to pale yellow solid
Hill FormulaC₂₁H₁₉ClN₄O₂·HCl
Chemical formulaC₂₁H₁₉ClN₄O₂·HCl
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary Target5-HT2C
Purity≥98% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
5.06417.0001 04055977243338

Documentation

SB 242084 Hydrochloride - CAS 1260505-34-7 - Calbiochem MSDS

Title

Safety Data Sheet (SDS) 

References

Reference overview
Manvich, D. F., et al. 2012. J Pharmacol. Exp. Ther. 342, 761.
Burghardt, N. S., et al. 2007. Biol Psychiatry 62, 1111.
Sharif, N. A., et al. 2007. J. Ocul. Pharmacol. Ther. 23, 1.
Knight A. R., et al. 2004. Naunyn Schmiedebergs Arch. Pharmacol. 370, 114.
Kennett G.A., et al. 1997. Neuropharmacol. 36, 609.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision09-June-2023 JSW
Synonyms5-HT2C receptor antagonist, SB 242084 Hydrochloride, SB-242084 Hydrochloride, SB242084 Hydrochloride
DescriptionA selective, brain-penetrant 5-HT2C receptor antagonist (pKi 8.2-9.0 ), with some effects on the 5-HT2B receptor (pKi 6.8-7.0) and 5-HT2A receptor (pKi 6.1-6.8). SB 242084 has been shown to increase the effectiveness of the selective serotonin reuptake inhibitor (SSRI) class of antidepressants, and may also reduce their side effects. In animal studies, SB-242,084 produced stimulant-type activity and reinforcing effects, somewhat similar to but much weaker than cocaine or amphetamines. In vivo (ocular) IC50 values reported at 2.08 µM.
FormOff-white to pale yellow solid
CAS number1260505-34-7
Chemical formulaC₂₁H₁₉ClN₄O₂·HCl
Structure formulaStructure formula
Purity≥98% by HPLC
SolubilityDMSO (50 mM) or H₂O (50 mM)
Storage Protect from light
-20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesManvich, D. F., et al. 2012. J Pharmacol. Exp. Ther. 342, 761.
Burghardt, N. S., et al. 2007. Biol Psychiatry 62, 1111.
Sharif, N. A., et al. 2007. J. Ocul. Pharmacol. Ther. 23, 1.
Knight A. R., et al. 2004. Naunyn Schmiedebergs Arch. Pharmacol. 370, 114.
Kennett G.A., et al. 1997. Neuropharmacol. 36, 609.