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567733 S1P₁ Receptor Agonist, SEW2871 - CAS 256414-75-2 - Calbiochem

S1P₁ Receptor Agonist, SEW2871 - CAS 256414-75-2 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Sphingosine-1-Phosphate₁ Receptor S1P1 Agonist, 5-(4-Phenyl-5-trifluoromethylthiophen-2-yl)-3-(3-trifluoromethylphenyl)-(1,2,4)-oxadiazole, SEW2871

Primary Target: S1P1 Receptor
567733
  
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
256414-75-2C₂₀H₁₀F₆N₂OS
Description
Overview

This product has been discontinued.



A cell-permeable oxadiazolothienyl compound that acts as a potent and highly selective S1P1 agonist (EC50 = 13 nM and 20.7 nM in GTPS1Pγ binding assay using human and murine S1P1, respectively). Shown to induce S1P1-mediated cellular functions in vitro and peripheral blood lymphopenia (oral ED50 = 5.5 mg/kg) in mice in vivo. Unlike sphingosine-1-phosphate (Cat. No. 567727) and other known S1P receptor agonists, SEW2871 exhibits no activity towards other S1P receptor subtypes, S1P2-5, even at concentrations as high as 10 µM.
Catalogue Number567733
Brand Family Calbiochem®
SynonymsSphingosine-1-Phosphate₁ Receptor S1P1 Agonist, 5-(4-Phenyl-5-trifluoromethylthiophen-2-yl)-3-(3-trifluoromethylphenyl)-(1,2,4)-oxadiazole, SEW2871
References
ReferencesSanna, M.G., et al. 2004. J. Biol. Chem. 279, 13839.
Product Information
CAS number256414-75-2
ATP CompetitiveN
FormWhite solid
Hill FormulaC₂₀H₁₀F₆N₂OS
Chemical formulaC₂₀H₁₀F₆N₂OS
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetS1P1 Receptor
Primary Target IC<sub>50</sub>EC50 = 13 nM and 20.7 nM in GTPS1Pγ binding assay using human and murine S1P1, respectively
Purity≥98% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
567733 0

Documentation

S1P₁ Receptor Agonist, SEW2871 - CAS 256414-75-2 - Calbiochem MSDS

Title

Safety Data Sheet (SDS) 

S1P₁ Receptor Agonist, SEW2871 - CAS 256414-75-2 - Calbiochem Certificates of Analysis

TitleLot Number
567733

References

Reference overview
Sanna, M.G., et al. 2004. J. Biol. Chem. 279, 13839.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision02-April-2008 RFH
SynonymsSphingosine-1-Phosphate₁ Receptor S1P1 Agonist, 5-(4-Phenyl-5-trifluoromethylthiophen-2-yl)-3-(3-trifluoromethylphenyl)-(1,2,4)-oxadiazole, SEW2871
DescriptionA cell-permeable, potent, and highly selective S1P1 agonist (EC50 = 13 nM and 20.7 nM in GTPS1Pγ binding assay using human and murine S1P1, respectively). Shown to induce S1P1-mediated cellular functions in vitro and peripheral blood lymphopenia (oral ED50 = 5.5 mg/kg) in mice in vivo. Unlike sphingosine-1-phosphate (Cat. No. 567727) and other known S1P receptor agonists, SEW2871 exhibits no activity towards other S1P receptor subtypes, S1P2-5, even at concentrations as high as 10 µM.
FormWhite solid
Intert gas (Yes/No) Packaged under inert gas
CAS number256414-75-2
Chemical formulaC₂₀H₁₀F₆N₂OS
Structure formulaStructure formula
Purity≥98% by HPLC
SolubilityDMSO (5 mg/ml)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesSanna, M.G., et al. 2004. J. Biol. Chem. 279, 13839.