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505724 Rotigotine Hydrochloride - CAS 125572-93-2 - Calbiochem

Rotigotine Hydrochloride - CAS 125572-93-2 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: (6S)-5,6,7,8-Tetrahydro-6-[propyl[2­-(2-thienyl)ethyl]amino]-1-naphthalenol Hydrochloride, Dopamine Receptor Agonist, Rotigotine Hydrochloride, Neupro

Primary Target: D3
505724
  
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
125572-93-2C₁₉H₂₅NOS•HCl
Description
Overview

This product has been discontinued.



A highly potent non-ergoline dopamine D2 and D3 receptor agonist (Ki = 13 and 0.71 nM for D2 and D3 respectively). Also displays significant affinity for 5-HT1A and adrenergic α2B receptors. Transdermally used in treatment of Parkinson′s disease and restless legs syndrome.
Catalogue Number505724
Brand Family Calbiochem®
Synonyms(6S)-5,6,7,8-Tetrahydro-6-[propyl[2­-(2-thienyl)ethyl]amino]-1-naphthalenol Hydrochloride, Dopamine Receptor Agonist, Rotigotine Hydrochloride, Neupro
References
ReferencesSplinter, M. Y. 2007. Ann. Pharmacother. 41, 285.
Pfeiffer, R. F. 2002. Drugs Aging. 19, 561.
Product Information
CAS number125572-93-2
FormWhite solid
Hill FormulaC₁₉H₂₅NOS•HCl
Chemical formulaC₁₉H₂₅NOS•HCl
Structure formula ImageStructure formula Image
Applications
Biological Information
Primary TargetD3
Primary Target K<sub>i</sub>0.71 nM for D3
Purity≥99% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
505724 0

Documentation

Rotigotine Hydrochloride - CAS 125572-93-2 - Calbiochem MSDS

Title

Safety Data Sheet (SDS) 

References

Reference overview
Splinter, M. Y. 2007. Ann. Pharmacother. 41, 285.
Pfeiffer, R. F. 2002. Drugs Aging. 19, 561.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision30-August-2013 JSW
Synonyms(6S)-5,6,7,8-Tetrahydro-6-[propyl[2­-(2-thienyl)ethyl]amino]-1-naphthalenol Hydrochloride, Dopamine Receptor Agonist, Rotigotine Hydrochloride, Neupro
DescriptionA highly potent non-ergoline dopamine D2 and D3 receptor agonist (Ki = 13 and 0.71 nM for D2 and D3 respectively). Also displays significant affinity for 5-HT1A and adrenergic α2B receptors. Transdermally used in treatment of Parkinson′s disease and restless legs syndrome.
FormWhite solid
CAS number125572-93-2
Chemical formulaC₁₉H₂₅NOS•HCl
Structure formulaStructure formula
Purity≥99% by HPLC
SolubilityDMSO (100 mM)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesSplinter, M. Y. 2007. Ann. Pharmacother. 41, 285.
Pfeiffer, R. F. 2002. Drugs Aging. 19, 561.