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557514 Ro-31-8425 - CAS 131848-97-0 - Calbiochem

A potent, cell-permeable, reversible, ATP-competitive, and selective protein kinase C inhibitor (IC₅₀ = 15 nM for rat brain PKC).

Ro-31-8425 - CAS 131848-97-0 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 2-[8-(Aminomethyl)-6,7,8,9-tetrahydropyrido[1,2-a]indol-3-yl]-3-(1-methyl-1H-indol-3-yl)maleimide, HCl, Bisindolylmaleimide X, HCl

Primary Target: PKC
557514
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
131848-97-0C₂₆H₂₄N₄O₂ · HCl

Products

Catalogue NumberPackaging Qty/Pack
557514-1MG Plastová ampulka 1 mg
Description
OverviewA potent, cell-permeable, reversible, ATP-competitive, and selective protein kinase C inhibitor (IC50 = 15 nM for rat brain PKC). Exhibits some degree of isozyme specificity (IC50 = 8 nM for PKCα, 8 nM for PKCβI, 14 nM for PKCβII, 13 nM for PKCγ, and 39 nM for PKCε). Upregulates CD11a expression and enhances mesenchymal stromal cell adhesion under flow.
Catalogue Number557514
Brand Family Calbiochem®
Synonyms2-[8-(Aminomethyl)-6,7,8,9-tetrahydropyrido[1,2-a]indol-3-yl]-3-(1-methyl-1H-indol-3-yl)maleimide, HCl, Bisindolylmaleimide X, HCl
References
ReferencesLevy, O., et al. 2015. Cell Reports 10, In press.
Merritt, J.E., et al. 1997. Cell Signal 9, 53.
Wilkinson, S.E., et al. 1993. Biochem. J. 294, 335.
Product Information
CAS number131848-97-0
ATP CompetitiveY
FormRed to orange-red solid
Hill FormulaC₂₆H₂₄N₄O₂ · HCl
Chemical formulaC₂₆H₂₄N₄O₂ · HCl
ReversibleY
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetPKC
Primary Target IC<sub>50</sub>15 nM for rat brain PKC; 8 nM for PKCα, 8 nM for PKCβI, 14 nM for PKCβII, 13 nM for PKCγ, and 39 nM for PKCε
Purity≥94% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
R PhraseR: 36/37/38

Irritating to eyes, respiratory system and skin.
S PhraseS: 26-36

In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
Wear suitable protective clothing.
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Irritant
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
557514-1MG 04055977192971

Documentation

Ro-31-8425 - CAS 131848-97-0 - Calbiochem MSDS

Title

Safety Data Sheet (SDS) 

Ro-31-8425 - CAS 131848-97-0 - Calbiochem Certificates of Analysis

TitleLot Number
557514

References

Reference overview
Levy, O., et al. 2015. Cell Reports 10, In press.
Merritt, J.E., et al. 1997. Cell Signal 9, 53.
Wilkinson, S.E., et al. 1993. Biochem. J. 294, 335.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision22-May-2018 JSW
Synonyms2-[8-(Aminomethyl)-6,7,8,9-tetrahydropyrido[1,2-a]indol-3-yl]-3-(1-methyl-1H-indol-3-yl)maleimide, HCl, Bisindolylmaleimide X, HCl
DescriptionA potent, cell-permeable, reversible, ATP-competitive, and selective protein kinase C inhibitor (IC50 = 15 nM for rat brain PKC). Exhibits some degree of isozyme specificity (IC50 = 8 nM for PKCα, 8 nM for PKCβI, 14 nM for PKCβII, 13 nM for PKCγ, and 39 nM for PKCε). Shows slight selectivity for the conventional PKC isozymes PKCα, PKCβ, and PKCγ over the Ca2+-independent PKC isozyme PKCε. Upregulates CD11a expression and enhances mesenchymal stromal cell adhesion under flow.
FormRed to orange-red solid
CAS number131848-97-0
Chemical formulaC₂₆H₂₄N₄O₂ · HCl
Structure formulaStructure formula
Purity≥94% by HPLC
SolubilityDMSO (10 mg/ml)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Irritant
ReferencesLevy, O., et al. 2015. Cell Reports 10, In press.
Merritt, J.E., et al. 1997. Cell Signal 9, 53.
Wilkinson, S.E., et al. 1993. Biochem. J. 294, 335.