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SCM075 ROCK Inhibitor (Y-27632)

The ROCK Inhibitor (Y-27632) is available in a 5 mg format & has been optimized & validated for cell culture & Neuroscience applications.

ROCK Inhibitor (Y-27632) MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Key Applications: Cell Culture, Neuroscience
SCM075
5 mg  
Purchase on Sigma-Aldrich

Overview

Replacement Information

Key Spec Table

Key Applications
CULT, Neuroscience
Description
Catalogue NumberSCM075
DescriptionROCK Inhibitor (Y-27632)
Background InformationROCK Inhibitor (Y-27632) is a selective, ATP-competitive inhibitor of Rho-associated protein kinase (ROCK) including p160Rock (Ki=140nM) and Rock-II. Also acts as a potent inhibitor of agonist-induced Ca2+ sensitization of myosin phosphorylation and smooth muscle contraction. One-hour treatment with 10uM Y-27632 blocks apoptosis of dissociated cultured human embryonic stem cells (hESCs), increases survival and cloning efficiency of hESCs without affecting their pluripotency1. Recently, some reports showed that the application of Y-27632 and Accutase (Cat. No. SCR005), a formulated mixture of digestive enzymes, enhances the post-thaw survival rate of single hESCs using conventional slow freezing and rapid thawing methods
References
Product Information
HS Code2933 39 99
Quality LevelMQ100
Applications
ApplicationThe ROCK Inhibitor (Y-27632) is available in a 5 mg format & has been optimized & validated for cell culture & Neuroscience applications.
Key Applications
  • Cell Culture
  • Neuroscience
Biological Information
Media FormLiquid
Molecular Weight320.26 g/mol
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsBefore Reconstitution: Maintain at -20ºC, protected from light for 2 years. After Reconstitution: 1 year at -20ºC, protected from light
Packaging Information
Material Size5 mg
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
SCM075 04053252374654

Documentation

ROCK Inhibitor (Y-27632) MSDS

Title

Safety Data Sheet (SDS) 

ROCK Inhibitor (Y-27632) Certificates of Analysis

TitleLot Number
ROCK Inhibitor (Y-27632) 5 mg 2975574
ROCK Inhibitor (Y-27632) 5 mg 2934776
ROCK Inhibitor (Y-27632) 5 mg 3091588
ROCK Inhibitor (Y-27632) 5 mg 2829752
ROCK Inhibitor (Y-27632) 5 mg - 2427507 2427507
ROCK Inhibitor (Y-27632) 5 mg - 2053029 2053029
ROCK Inhibitor (Y-27632) 5 mg - 2196069 2196069
ROCK Inhibitor (Y-27632) 5 mg - 2325726 2325726
ROCK Inhibitor (Y-27632) 5 mg - 3236527 3236527
ROCK Inhibitor (Y-27632) 5 mg - 3287863 3287863
Show more

Brochure

Title
Human Stem Cell Systems

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Categories

Life Science Research > Cell Culture and Systems > Cell Culture Media and Supplements > Cell Culture Supplements > Media Supplements