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553514 RAD51 Inhibitor II, RI-1 - Calbiochem

RAD51 Inhibitor II, RI-1, CAS 415713-60-9, covalently binds to RAD51 at Cys319 and irreversibly destabilizes a protein-protein interface that is needed for filament formation & recombinase activity.

RAD51 Inhibitor II, RI-1 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 3-chloro-1-(3,4-dichlorophenyl)-4-morpholino-1H-pyrrole-2,5-dione

Primary Target: RAD51
553514
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Overview

Replacement Information

Key Spec Table

Empirical Formula
C₁₄H₁₁Cl₃N₂O₃

Products

Catalogue NumberPackaging Qty/Pack
553514-10MG Sklená flaša 10 mg
Description
OverviewA cell-permeable 1H-Pyrrole-2,3-dione derivative that covalently binds to RAD51 at Cys319 and irreversibly destabilizes a protein-protein interface that is essential for filament formation and recombinase activity. Stimulates single strand annealing at a 5-30 µM concentration. Inhibits subnuclear RAD51 foci formation following DNA damage without affecting replication protein A. Also, effectively sensitizes cancer cells to mitomycin C (~25 µM) and generate synergistic cell kill in RAD51C mutant cells and with lesser effect on RAD51 complemented cells. Satisfies all four Lipinski rules for predicting drug likeness.
Catalogue Number553514
Brand Family Calbiochem®
Synonyms3-chloro-1-(3,4-dichlorophenyl)-4-morpholino-1H-pyrrole-2,5-dione
References
ReferencesBudke, B., et al. 2012. Nucleic Acids Res. 40, 7347.
Product Information
FormBright yellow solid
Hill FormulaC₁₄H₁₁Cl₃N₂O₃
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
ApplicationRAD51 Inhibitor II, RI-1, CAS 415713-60-9, covalently binds to RAD51 at Cys319 and irreversibly destabilizes a protein-protein interface that is needed for filament formation & recombinase activity.
Biological Information
Primary TargetRAD51
Primary Target IC<sub>50</sub>5-30 µ
Purity≥99% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
553514-10MG 04055977193732

Documentation

RAD51 Inhibitor II, RI-1 - Calbiochem MSDS

Title

Safety Data Sheet (SDS) 

RAD51 Inhibitor II, RI-1 - Calbiochem Certificates of Analysis

TitleLot Number
553514

References

Reference overview
Budke, B., et al. 2012. Nucleic Acids Res. 40, 7347.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision21-September-2012 JSW
Synonyms3-chloro-1-(3,4-dichlorophenyl)-4-morpholino-1H-pyrrole-2,5-dione
DescriptionA cell-permeable 1H-Pyrrole-2,3-dione derivative that covalently binds to RAD51 at Cys319 and irreversibly destabilizes a protein-protein interface that is essential for filament formation and recombinase activity. Stimulates single strand annealing at a 5-30 µM concentration. Inhibits subnuclear RAD51 foci formation following DNA damage without affecting replication protein A. Also, effectively sensitizes cancer cells to mitomycin C (~25 µM) and generate synergistic cell kill in RAD51C mutant cells and with lesser effect on RAD51 complemented cells. Satisfies all four Lipinski rules for predicting drug likeness.
FormBright yellow solid
Intert gas (Yes/No) Packaged under inert gas
Structure formulaStructure formula
Purity≥99% by HPLC
SolubilityDMSO (50 mg/ml)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesBudke, B., et al. 2012. Nucleic Acids Res. 40, 7347.