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552233 QX-314 - CAS 21306-56-9 - Calbiochem

A quaternary lidocaine derivative, permanently charged, and lipophobic.

QX-314 - CAS 21306-56-9 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Primary Target: A powerful blocker of voltage-sensitive Na+ conductance
552233
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
21306-56-9C₁₆H₂₇BrN₂O

Products

Catalogue NumberPackaging Qty/Pack
552233-100MG Plastová ampulka 100 mg
Description
OverviewA quaternary lidocaine derivative, permanently charged, and lipophobic. A powerful blocker of voltage-sensitive Na+ conductance when applied intracellularly. Suppresses the generation of Na+-dependent spikes from inside the cell membrane, without affecting Ca2+ currents or glutamate-activated currents.
Catalogue Number552233
Brand Family Calbiochem®
References
ReferencesMooney, R. 1992. J. Neurosci. 12, 2464.
Regehr, W.G. and Tank, D.W. 1992. J. Neurosci. 12, 4202.
Product Information
CAS number21306-56-9
ATP CompetitiveN
FormLyophilized solid
Hill FormulaC₁₆H₂₇BrN₂O
Chemical formulaC₁₆H₂₇BrN₂O
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Biological activityfully active in neurophysiological testing
Primary TargetA powerful blocker of voltage-sensitive Na+ conductance
Purity≥99%
Physicochemical Information
Cell permeableN
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
R PhraseR: 36/37/38

Irritating to eyes, respiratory system and skin.
S PhraseS: 26-36

In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
Wear suitable protective clothing.
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Irritant
Storage +15°C to +30°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 6 weeks at 4°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
552233-100MG 04055977268331

Documentation

QX-314 - CAS 21306-56-9 - Calbiochem MSDS

Title

Safety Data Sheet (SDS) 

QX-314 - CAS 21306-56-9 - Calbiochem Certificates of Analysis

TitleLot Number
552233

References

Reference overview
Mooney, R. 1992. J. Neurosci. 12, 2464.
Regehr, W.G. and Tank, D.W. 1992. J. Neurosci. 12, 4202.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision29-June-2018 JSW
DescriptionA quaternary lidocaine derivative, permanently charged and lipophobic. A powerful blocker of voltage-sensitive Na+ conductance when applied intracellularly. Suppresses the generation of Na+-dependent spikes from inside the cell membrane, without affecting Ca2+ currents or glutamate-activated currents.
FormLyophilized solid
CAS number21306-56-9
Chemical formulaC₁₆H₂₇BrN₂O
Structure formulaStructure formula
Purity≥99%
Biological activityfully active in neurophysiological testing
SolubilityH₂O (3 mg/ml)
Storage Protect from light
+15°C to +30°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 6 weeks at 4°C.
Toxicity Irritant
ReferencesMooney, R. 1992. J. Neurosci. 12, 2464.
Regehr, W.G. and Tank, D.W. 1992. J. Neurosci. 12, 4202.