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533313 Pyruvate Kinase Inhibitor III - CAS 313701-92-7 - Calbiochem

PKM2 Inhibitor

Pyruvate Kinase Inhibitor III - CAS 313701-92-7 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 5-(2,5-Dimethyl-1H-pyrrol-1-yl)-2-hydroxybenzoic acid, PKM2 Inhibitor III

Primary Target: pyruvate kinases
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
313701-92-7C₁₃H₁₃NO₃
Description
OverviewA cell-permeable pyrrolyl-hydroxybenzoate compound that inhibits fructose-1,6-bisphosphate- (FBP-) dependent activation of pyruvate kinases PKM2 and PKL (IC50 10 to 50 µM), while exhibiting reduced potency against non-FBP-dependent PKM1 activity (81% inhibition of PKM2 vs. 34% inhibition of PKM1 at 30 µM). Lysates from inhibitor-treated (250 µM inhibitor treatment for 6 h) human lung cancer H1299 cells are shown to exhibit significantly reduced PKM2 activity (by 84%) even upon exogenous FBP addition. Inhibitor treatment (Effective conc. 50 to 100 µM) is also demonstrated to enhance cell death of IL-3-dependent murine pro-B lymphocytic FL5.12 and EGFR-signaling-dependent human lung adenocarcinoma HCC827 cultures upon IL-3 withdrawal and EGFR inhibitor treatment, respectively.

Please note that the molecular weight for this compound is batch-specific due to variable water content. Please refer to the vial label or the certificate of analysis for the batch-specific molecular weight. The molecular weight provided represents the baseline molecular weight without water.
Catalogue Number533313
Brand Family Calbiochem®
Synonyms5-(2,5-Dimethyl-1H-pyrrol-1-yl)-2-hydroxybenzoic acid, PKM2 Inhibitor III
DescriptionPyruvate Kinase Inhibitor III
References
ReferencesVander Heiden, M.G., et al. 2010. Biochem. Pharmacol. 79, 1118.
Product Information
CAS number313701-92-7
FormLight brown to brown solid
Hill FormulaC₁₃H₁₃NO₃
Chemical formulaC₁₃H₁₃NO₃
ReversibleY
Quality LevelMQ100
Applications
Biological Information
Primary Targetpyruvate kinases
Purity≥95% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 weeks at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
533313 0

Documentation

Pyruvate Kinase Inhibitor III - CAS 313701-92-7 - Calbiochem MSDS

Title

Safety Data Sheet (SDS) 

References

Reference overview
Vander Heiden, M.G., et al. 2010. Biochem. Pharmacol. 79, 1118.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision24-June-2016 JSW
Synonyms5-(2,5-Dimethyl-1H-pyrrol-1-yl)-2-hydroxybenzoic acid, PKM2 Inhibitor III
DescriptionA cell-permeable pyrrolyl-hydroxybenzoate compound that inhibits fructose-1,6-bisphosphate- (FBP-) dependent activation of pyruvate kinases PKM2 and PKL (IC50 10 to 50 µM), while exhibiting reduced potency against non-FBP-dependent PKM1 activity (81% inhibition of PKM2 vs. 34% inhibition of PKM1 at 30 µM). Lysates from inhibitor-treated (250 µM inhibitor treatment for 6 h) human lung cancer H1299 cells are shown to exhibit significantly reduced PKM2 activity (by 84%) even upon exogenous FBP addition. Inhibitor treatment (Effective conc. 50 to 100 µM) is also demonstrated to enhance cell death of IL-3-dependent murine pro-B lymphocytic FL5.12 and EGFR-signaling-dependent human lung adenocarcinoma HCC827 cultures upon IL-3 withdrawal and EGFR inhibitor treatment, respectively.
FormLight brown to brown solid
Intert gas (Yes/No) Packaged under inert gas
CAS number313701-92-7
Chemical formulaC₁₃H₁₃NO₃
Purity≥95% by HPLC
SolubilityDMSO (50 mg/ml)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 weeks at -20°C.
Toxicity Standard Handling
ReferencesVander Heiden, M.G., et al. 2010. Biochem. Pharmacol. 79, 1118.