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539483 Proteinase 3, Human Neutrophils

Proteinase 3, Human Neutrophils MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Myoblastin, PR3, PR3 Ag, PR III

539483
  
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Overview

Replacement Information
Description
Overview

This product has been discontinued.



Native, human proteinase 3 purified from neutrophils. A serine protease with proinflammatory properties, expressed mainly in neutrophils. Proteinase 3 is the antigen for anti-neutrophil cytoplasmic antibodies (ANCAs) of the cANCA (cytoplasmic subtype) class, frequently found in Wegener's granulomatosis.
Catalogue Number539483
Brand Family Calbiochem®
SynonymsMyoblastin, PR3, PR3 Ag, PR III
References
ReferencesUehara, A., et al. 2007. Mol. Immunol. 44, 3552.
Villegas-Mendez, A., et al. 2007. J. Thromb. Haemost. 5, 980.
Clin. Nephrol. 2005 Dec;64(6):453-9.
von Vietinghoff S., et al. 2005. Clin. Nephrol. 64, 453.
Wiesner, O., et al. 2005. FEBS Lett. 579, 5305.
Specks, U., et al. 1996. FEBS Lett. 390, 265.
Product Information
Unit of DefinitionOne unit is defined as the amount of enzyme that will hydrolyze one µmol methoxysuccinyl-Ala-Ala-Pro-Val-<i>p</i>NA per min at 37°C, pH 7.5.
FormLiquid
FormulationIn 150 mM NaCl, 50 mM sodium acetate, 0.1% Triton® X-100 detergent, pH 6.0.
Applications
Biological Information
Purity≥96% by SDS-PAGE
SourcePrepared from neutrophils that have been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.
Concentration Label Please refer to vial label for lot-specific concentration
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Blue Ice Only
Toxicity Standard Handling
Storage -20°C
Avoid freeze/thaw Avoid freeze/thaw
Do not freeze Ok to freeze
Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
539483 0

Documentation

Proteinase 3, Human Neutrophils Certificates of Analysis

TitleLot Number
539483

References

Reference overview
Uehara, A., et al. 2007. Mol. Immunol. 44, 3552.
Villegas-Mendez, A., et al. 2007. J. Thromb. Haemost. 5, 980.
Clin. Nephrol. 2005 Dec;64(6):453-9.
von Vietinghoff S., et al. 2005. Clin. Nephrol. 64, 453.
Wiesner, O., et al. 2005. FEBS Lett. 579, 5305.
Specks, U., et al. 1996. FEBS Lett. 390, 265.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision17-February-2009 JSW
SynonymsMyoblastin, PR3, PR3 Ag, PR III
DescriptionNative, human proteinase 3 purified from neutrophils. A serine protease with proinflammatory properties, expressed mainly in neutrophils. Proteinase 3 is the antigen for anti-neutrophil cytoplasmic antibodies (ANCAs) of the cANCA (cytoplasmic subtype) class, frequently found in Wegener's granulomatosis.
FormLiquid
FormulationIn 150 mM NaCl, 50 mM sodium acetate, 0.1% Triton® X-100 detergent, pH 6.0.
Concentration Label Please refer to vial label for lot-specific concentration
SourcePrepared from neutrophils that have been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.
Purity≥96% by SDS-PAGE
Unit definitionOne unit is defined as the amount of enzyme that will hydrolyze one µmol methoxysuccinyl-Ala-Ala-Pro-Val-pNA per min at 37°C, pH 7.5.
Storage Avoid freeze/thaw
-20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
Toxicity Standard Handling
ReferencesUehara, A., et al. 2007. Mol. Immunol. 44, 3552.
Villegas-Mendez, A., et al. 2007. J. Thromb. Haemost. 5, 980.
Clin. Nephrol. 2005 Dec;64(6):453-9.
von Vietinghoff S., et al. 2005. Clin. Nephrol. 64, 453.
Wiesner, O., et al. 2005. FEBS Lett. 579, 5305.
Specks, U., et al. 1996. FEBS Lett. 390, 265.