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528884 Polo-like Kinase Inhibitor V, Poloxin - CAS 321688-88-4 - Calbiochem

The Polo-like Kinase Inhibitor V, Poloxin, also referenced under CAS 321688-88-4, controls the biological activity of Polo-like Kinase. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

Polo-like Kinase Inhibitor V, Poloxin - CAS 321688-88-4 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Polo-like Kinase Inhibitor V, 2-isopropyl-5-methyl-4-(2-methylbenzoyloxyimino)cyclohexa-2,5-dienone

528884
  
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
321688-88-4C₁₈H₁₉NO₃
Description
OverviewA thymoquinone derivative, non-ATP competitive Polo-like Kinase 1 (Plk1) inhibitor specifically targeting the polo-box domain (PBD) of Plk1 (IC50) = 4.8 µM. Reduces both chromosome and kinetochoral localization of Plk1, induces chromosome congression defects , mitotic arrest in prometaphase, and apoptosis in HeLa cells at 25 µM. Exhibits anti-proliferative effects in a range of cancer cell lines, and in a mouse Xenograft model involving HeLa and MDA-MB-231 cells at 40 mg/kg.
Catalogue Number528884
Brand Family Calbiochem®
SynonymsPolo-like Kinase Inhibitor V, 2-isopropyl-5-methyl-4-(2-methylbenzoyloxyimino)cyclohexa-2,5-dienone
References
ReferencesReindl, W., et al. 2008. Chem Biol. 15, 459.
Yuan, J., et al. 2011, Am J Pathol 179, 2091.
Product Information
CAS number321688-88-4
FormYellow solid
Hill FormulaC₁₈H₁₉NO₃
Chemical formulaC₁₈H₁₉NO₃
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Purity≥99% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
528884 0

Documentation

Polo-like Kinase Inhibitor V, Poloxin - CAS 321688-88-4 - Calbiochem MSDS

Title

Safety Data Sheet (SDS) 

References

Reference overview
Reindl, W., et al. 2008. Chem Biol. 15, 459.
Yuan, J., et al. 2011, Am J Pathol 179, 2091.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision15-June-2012 JSW
SynonymsPolo-like Kinase Inhibitor V, 2-isopropyl-5-methyl-4-(2-methylbenzoyloxyimino)cyclohexa-2,5-dienone
DescriptionA thymoquinone derivative, non-ATP competitive Polo-like Kinase 1 (Plk1) inhibitor specifically targeting the polo-box domain (PBD) of Plk1 (IC50) = 4.8 µM. Reduces both chromosome and kinetochoral localization of Plk1, induces chromosome congression defects , mitotic arrest in prometaphase, and apoptosis in HeLa cells at 25 µM. Exhibits anti-proliferative effects in a range of cancer cell lines, and in a mouse Xenograft model involving HeLa and MDA-MB-231 cells at 40 mg/kg.
FormYellow solid
Intert gas (Yes/No) Packaged under inert gas
CAS number321688-88-4
Chemical formulaC₁₈H₁₉NO₃
Structure formulaStructure formula
Purity≥99% by HPLC
SolubilityDMSO (25 mg/ml; clear, yellow solution)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesReindl, W., et al. 2008. Chem Biol. 15, 459.
Yuan, J., et al. 2011, Am J Pathol 179, 2091.