Millipore Sigma Vibrant Logo
Attention: We have moved. Merck Millipore products are no longer available for purchase on MerckMillipore.com.Learn More

524751 Phosphodiesterase 7A1, Human, Recombinant, S. frugiperda

Phosphodiesterase 7A1, Human, Recombinant, S. frugiperda MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: hPDE7A1

524751
Purchase on Sigma-Aldrich

Overview

Replacement Information

Products

Catalogue NumberPackaging Qty/Pack
524751-10U Plastová ampulka 10 u
Description
OverviewFull-length, recombinant, human phosphodiesterdase 7A1 (PDE7A1) expressed in S. frugiperda insect cells using a baculovirus expression system. PDE7A1 is required for T-cell activation induced by the costimulation of CD3 and CD28 receptors. Increased PDE7A1 correlates with a decrease in cAMP, increased IL-2, and increased cell proliferation. Supplied as a partially purified preparation of catalytically active enzyme useful for inhibitor and activator assays.
Catalogue Number524751
Brand Family Calbiochem®
SynonymshPDE7A1
Application Data
Increasing concentrations of SB36207, a PDE7A1 inhibitor, were mixed with the enzyme and the activity was measured.
References
ReferencesHan, P., et al. 2006. J. Biol. Chem. 281, 15050.
Lugnier, C. 2006. Pharmacol Ther. 109, 366.
Bloom, T.J., and Beavo, J.A. 1996. Proc. Natl. Acad. Sci. U S A 93, 14188.
Product Information
Activity≥ 0.5 U/µl
Unit of DefinitionOne unit is defined as the amount of enzyme that is required to convert 1 pmol cAMP to AMP per min at 30°C, pH 7.5.
FormLiquid
FormulationIn 150 mM NaCl, 10 mM Tris, 0.1% NP-40, pH 8.3.
Quality LevelMQ100
Applications
Biological Information
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Dry Ice Only
Toxicity Standard Handling
Storage ≤ -70°C
Avoid freeze/thaw Avoid freeze/thaw
Do not freeze Ok to freeze
Special InstructionsFollowing initial thaw, aliquot and freeze (-70°C).
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
524751-10U 04055977197099

Documentation

Phosphodiesterase 7A1, Human, Recombinant, S. frugiperda MSDS

Title

Safety Data Sheet (SDS) 

Phosphodiesterase 7A1, Human, Recombinant, S. frugiperda Certificates of Analysis

TitleLot Number
524751

References

Reference overview
Han, P., et al. 2006. J. Biol. Chem. 281, 15050.
Lugnier, C. 2006. Pharmacol Ther. 109, 366.
Bloom, T.J., and Beavo, J.A. 1996. Proc. Natl. Acad. Sci. U S A 93, 14188.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision17-December-2008 JSW
SynonymshPDE7A1
Application Data
Increasing concentrations of SB36207, a PDE7A1 inhibitor, were mixed with the enzyme and the activity was measured.
DescriptionFull-length, recombinant, human phosphodiesterdase 7A1 (PDE7A1) expressed in S. frugiperda insect cells using a baculovirus expression system. PDE7A1 is required for T-cell activation induced by the costimulation of CD3 and CD28 receptors. Increased PDE7A1 correlates with a decrease in cAMP, increased IL-2, and increased cell proliferation. Supplied as a partially purified preparation of catalytically active enzyme useful for inhibitor and activator assays.
FormLiquid
FormulationIn 150 mM NaCl, 10 mM Tris, 0.1% NP-40, pH 8.3.
Activity≥ 0.5 U/µl
Unit definitionOne unit is defined as the amount of enzyme that is required to convert 1 pmol cAMP to AMP per min at 30°C, pH 7.5.
Storage Avoid freeze/thaw
≤ -70°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing initial thaw, aliquot and freeze (-70°C).
Toxicity Standard Handling
ReferencesHan, P., et al. 2006. J. Biol. Chem. 281, 15050.
Lugnier, C. 2006. Pharmacol Ther. 109, 366.
Bloom, T.J., and Beavo, J.A. 1996. Proc. Natl. Acad. Sci. U S A 93, 14188.