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516854 Pertussis Toxin, A Protomer, Bordetella pertussis - Calbiochem

Pertussis Toxin, A Protomer, Bordetella pertussis - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
516854
  
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Overview

Replacement Information
Description
Overview

This product has been discontinued.



Enzymatic component of the holotoxin. Has both NAD-glycohydrolase and ADP-ribosyltransferase activities. Inhibits neutrophil-mediated inflammation in vivo via its ADP-ribosylation activity. Unable to penetrate cells in the absence of the B oligomer.
Catalogue Number516854
Brand Family Calbiochem®
References
ReferencesBrito, G.A., et al. 1997. Infect. Immun. 65, 1114.
Gill, D.M., and Coburn, J., 1988. Biochim. Biophys. Acta 954, 65.
Kaslow, H.R., and Lesikar, D.D., 1987. Biochemistry 26, 4397.
Burns, D.L., and Manclark, C.R., 1986. J. Biol. Chem. 261, 4324.
Moss, J., et al. 1983. J. Biol. Chem. 258, 11879.
Tamura, M., et al. 1982. Biochemistry 21, 5516.
Product Information
ATP CompetitiveN
FormLyophilized
FormulationLyophilized from 10 mM Tris, 100 µM EDTA, 0.04% CHAPS, pH 8.0.
ReversibleN
Applications
Biological Information
Primary TargetHas both NAD-glycohydrolase and ADP-ribosyltransferase activities
PuritySingle major band by SDS-PAGE
Physicochemical Information
Cell permeableN
Contaminants≤0.1% holotoxin by CHO cell assay
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
R PhraseR: 23/24/25

Toxic by inhalation, in contact with skin and if swallowed.
S PhraseS: 36/37/39-45

Wear suitable protective clothing, gloves and eye/face protection.
In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Toxic
Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Storage +2°C to +8°C
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, refrigerate (4°C). Stock solutions, prepared from high ionic strength buffers, are stable for up to 3 months at 4°C.
Canadian export regulations Due to the country and/or U.S. state of origin of the animal material used in this product, this product may not be exported to Canada.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
516854 0

Documentation

Pertussis Toxin, A Protomer, Bordetella pertussis - Calbiochem MSDS

Title

Safety Data Sheet (SDS) 

Pertussis Toxin, A Protomer, Bordetella pertussis - Calbiochem Certificates of Analysis

TitleLot Number
516854

References

Reference overview
Brito, G.A., et al. 1997. Infect. Immun. 65, 1114.
Gill, D.M., and Coburn, J., 1988. Biochim. Biophys. Acta 954, 65.
Kaslow, H.R., and Lesikar, D.D., 1987. Biochemistry 26, 4397.
Burns, D.L., and Manclark, C.R., 1986. J. Biol. Chem. 261, 4324.
Moss, J., et al. 1983. J. Biol. Chem. 258, 11879.
Tamura, M., et al. 1982. Biochemistry 21, 5516.

Brochure

Title
Activators and Inhibitors of Adenylate Cyclase Technical Bulletin
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision19-August-2008 RFH
DescriptionEnzymatic component of the holotoxin. Has NAD-glycohydrolase activities. Unable to penetrate cells in the absence of the B oligomer.
FormLyophilized
FormulationLyophilized from 10 mM Tris, 100 µM EDTA, 0.04% CHAPS, pH 8.0.
PuritySingle major band by SDS-PAGE
Contaminants≤0.1% holotoxin by CHO cell assay
SolubilityReconstitute with 500 µl sterile dH₂O or high ionic buffer.
Storage +2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, refrigerate (4°C). Stock solutions, prepared from high ionic strength buffers, are stable for up to 3 months at 4°C.
Toxicity Toxic
ReferencesBrito, G.A., et al. 1997. Infect. Immun. 65, 1114.
Gill, D.M., and Coburn, J., 1988. Biochim. Biophys. Acta 954, 65.
Kaslow, H.R., and Lesikar, D.D., 1987. Biochemistry 26, 4397.
Burns, D.L., and Manclark, C.R., 1986. J. Biol. Chem. 261, 4324.
Moss, J., et al. 1983. J. Biol. Chem. 258, 11879.
Tamura, M., et al. 1982. Biochemistry 21, 5516.

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Categories

Life Science Research > Inhibitors and Biochemicals > Biochemicals > Toxins