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531294 Perk Inhibitor III, LDN-0070977 - Calbiochem

A cell-permeable, reversible, and non ATP-competitive inhibitor of PERK (PKR-like ER kinase, IC₅₀ = 7.04 µM) and blocks PERK-dependent phosphorylation of elF2a.

Perk Inhibitor III, LDN-0070977 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: PKR-like ER kinase Inhibitor, LDN-0070977, LDN0070977, LDN 0070977

Primary Target: PERK
531294
  
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Overview

Replacement Information

Key Spec Table

Empirical Formula
C₁₂H₈N₂O
Description
Overview

This product has been discontinued.



A cell-permeable tricyclic heterocycle oxime that acts as a reversible and non ATP-competitive inhibitor of PERK (PKR-like ER kinase, IC50 = 7.04 µM) and blocks PERK-dependent phosphorylation of elF2a. Shown to reduce thapsigargin-induced elF2a phosphorylation in mouse embryonic fibroblasts over a wide range. Does not exhibit any cellular toxicity up to 50 µM levels.

Please note that the molecular weight for this compound is batch-specific due to variable water content.

Catalogue Number531294
Brand Family Calbiochem®
SynonymsPKR-like ER kinase Inhibitor, LDN-0070977, LDN0070977, LDN 0070977
References
ReferencesPytel, D., et al. 2014. J. Biomol. Screen. 19, 1024.
Product Information
FormOff-white powder
Hill FormulaC₁₂H₈N₂O
Chemical formulaC₁₂H₈N₂O
ReversibleY
Quality LevelMQ100
Applications
Biological Information
Primary TargetPERK
Primary Target IC<sub>50</sub>7µ
Purity≥98% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
531294 0

Documentation

Perk Inhibitor III, LDN-0070977 - Calbiochem MSDS

Title

Safety Data Sheet (SDS) 

References

Reference overview
Pytel, D., et al. 2014. J. Biomol. Screen. 19, 1024.

Technical Info

Title
Characterization of Estrogen Receptor α Phosphorylation Sites in Breast Cancer Tissue Using the SNAP i.d® 2.0 System
White Paper: Further considerations of antibody validation and usage.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision18-March-2015 JSW
SynonymsPKR-like ER kinase Inhibitor, LDN-0070977, LDN0070977, LDN 0070977
DescriptionA cell-permeable tricyclic heterocycle oxime that acts as a reversible and non ATP-competitive inhibitor of PERK (PKR-like ER kinase, IC50 = 7.04 µM) and blocks PERK-dependent phosphorylation of elF2a. Shown to reduce thapsigargin-induced elF2a phosphorylation in mouse embryonic fibroblasts over a wide range. Does not exhibit any cellular toxicity up to 50 µM levels.
FormOff-white powder
Intert gas (Yes/No) Packaged under inert gas
Chemical formulaC₁₂H₈N₂O
Purity≥98% by HPLC
SolubilityDMSO (50 mg/ml)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesPytel, D., et al. 2014. J. Biomol. Screen. 19, 1024.