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529627 PPIase-Parvulin Inhibitor - CAS 64005-90-9 - Calbiochem

PPIase-Parvulin Inhibitor - CAS 64005-90-9 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: PiB, Diethyl-1,3,6,8-tetrahydro-1,3,6,8-tetraoxobenzo[lmn][3,8]phenanthroline-2,7-diacetate

Primary Target: Pin1/Par14 PPIase (peptidyl prolyl cis-trans isomerase) activity
529627
  
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
64005-90-9C₂₂H₁₈N₂O₈
Description
Overview

This product has been discontinued.



A cell-permeable napthalenetetracarboxylic-bisimide compound that displays anti-proliferative properties (IC50 < 5 µM against a panel of human cancer cell lines). Causes cell cycle arrest and acts as a potent, selective, reversible, competitive, active site binding inhibitor of Pin1/Par14 PPIase (peptidyl prolyl cis-trans isomerase) activity (IC50 = ~ 1.5 µM). Does not bind to DNA or functions as a topoisomerase I inhibitor.
Catalogue Number529627
Brand Family Calbiochem®
SynonymsPiB, Diethyl-1,3,6,8-tetrahydro-1,3,6,8-tetraoxobenzo[lmn][3,8]phenanthroline-2,7-diacetate
References
ReferencesUchida, T., et al. 2003. Chem. Biol. 10, 15.
Product Information
CAS number64005-90-9
ATP CompetitiveY
FormBrownish solid
Hill FormulaC₂₂H₁₈N₂O₈
Chemical formulaC₂₂H₁₈N₂O₈
ReversibleY
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetPin1/Par14 PPIase (peptidyl prolyl cis-trans isomerase) activity
Primary Target IC<sub>50</sub>< 5 µM for anti-proliferative properties against a panel of human cancer cell lines; ~ 1.5 µM inhibiting Pin1/Par14 PPIase (peptidyl prolyl cis-trans isomerase) activity
Purity≥95% by NMR
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
529627 0

Documentation

PPIase-Parvulin Inhibitor - CAS 64005-90-9 - Calbiochem MSDS

Title

Safety Data Sheet (SDS) 

PPIase-Parvulin Inhibitor - CAS 64005-90-9 - Calbiochem Certificates of Analysis

TitleLot Number
529627

References

Reference overview
Uchida, T., et al. 2003. Chem. Biol. 10, 15.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision18-April-2011 RFH
SynonymsPiB, Diethyl-1,3,6,8-tetrahydro-1,3,6,8-tetraoxobenzo[lmn][3,8]phenanthroline-2,7-diacetate
DescriptionA cell-permeable, napthalenetetracarboxylic-bismide compound that displays anti-proliferative properties (IC50 < 5 µM against a panel of human cancer cell lines). Causes cell cycle arrest and acts as a potent, selective, reversible, competitive, active site-binding inhibitor of Pin1/Par14 peptidylprolyl cis-trans isomerase (PPIase) activity (IC50 ~ 1.5 µM). Does not bind to DNA or function as a topoisomerase I inhibitor.
FormBrownish solid
Intert gas (Yes/No) Packaged under inert gas
CAS number64005-90-9
Chemical formulaC₂₂H₁₈N₂O₈
Structure formulaStructure formula
Purity≥95% by NMR
SolubilityChloroform (1 mg/ml) or Ethanol (250 µg/ml, cloudy suspension)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesUchida, T., et al. 2003. Chem. Biol. 10, 15.