529598 Sigma-AldrichPP1 Analog IV, 3-IB-PP1 - CAS 1174182-24-1 - Calbiochem
A cell-permeable enlarged PP1 analog that acts as a potent, ATP-competitive and reversible inhibitor of asAkt1/2/3.
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Synonyms: 3-Iodobenzyl PP1 analog
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Overview
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Key Spec Table
| CAS # | Empirical Formula |
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| 1174182-24-1 | C₁₆H₁₈IN₅ |
Products
| Catalogue Number | Packaging | Qty/Pack | |
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| 529598-10MG | Sklená flaša | 10 mg |
| Description | |
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| Overview | A cell-permeable enlarged PP1 (Cat. No. 567809) analog that acts as a potent, ATP-competitive and reversible inhibitor of asAkt1/2/3 (IC50 = 28, 240 and 120 nM, respectively) over wtAkt1/2/3 (IC50 = >10 µM). Shown to hyperphosphorylate Akt-Ser473 and -Thr308 in HEK293 cells coexpressed with myr-HA-asAkt1 or myr-HA-asAkt1/2/3 with no effect on pGSK-3βSer9 levels and wtAkt expressing cells. Also, specifically blocks the inhibitory function of membrane asCsk with diminished activity towards wtCsk, induces phosphorylation of Lck-Tyr394 and ERK1/2 in primary mouse T cells (EC50 ~0.5 µM) and rapidly activates T cell receptor signaling. |
| Catalogue Number | 529598 |
| Brand Family | Calbiochem® |
| Synonyms | 3-Iodobenzyl PP1 analog |
| References | |
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| References | Schoenborn, J.R., et al. 2011. Sci. Signal. 4, ra59. Okuzumi, T., et al. 2009. Nat. Chem. Bio. 5, 484. |
| Product Information | |
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| CAS number | 1174182-24-1 |
| Form | White powder |
| Hill Formula | C₁₆H₁₈IN₅ |
| Chemical formula | C₁₆H₁₈IN₅ |
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| Quality Level | MQ100 |
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| Purity | ≥97% by HPLC |
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| Packaged under inert gas | Packaged under inert gas |
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| Specifications |
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| Global Trade Item Number | |
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| Catalogue Number | GTIN |
| 529598-10MG | 04055977269918 |
Documentation
PP1 Analog IV, 3-IB-PP1 - CAS 1174182-24-1 - Calbiochem MSDS
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PP1 Analog IV, 3-IB-PP1 - CAS 1174182-24-1 - Calbiochem Certificates of Analysis
| Title | Lot Number |
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| 529598 |
References
| Reference overview |
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| Schoenborn, J.R., et al. 2011. Sci. Signal. 4, ra59. Okuzumi, T., et al. 2009. Nat. Chem. Bio. 5, 484. |