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370655 PKG Iα Inhibitor, Cell-Permeable - Calbiochem

The PKG Iα Inhibitor, Cell-Permeable controls the biological activity of PKG Iα. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

PKG Iα Inhibitor, Cell-Permeable - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: DT-3, RQIKIWFQNRRMKWKKLRKKKKKH, PKG Inhibitor VIII

Primary Target: PKG1α
370655
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Overview

Replacement Information

Key Spec Table

Empirical Formula
C₁₅₂H₂₅₈N₅₂O₂₈S

Products

Catalogue NumberPackaging Qty/Pack
370655-1MG Plastová ampulka 1 mg
Description
OverviewA highly potent, reversible, and substrate competitive membrane-permeable Drosophila Antennapedia homeodomain fused-peptide that selectively inhibits protein kinase G Iα (Ki = 25 nM). Shown to efficiently translocate into arterial smooth muscle cells and inhibit NO-induced vasodilation (ED50 = 47 µM). Inhibits protein kinase A at much higher concentrations (Ki = 493 µM). The carrier peptide is also available under Cat. no. 287895.
Catalogue Number370655
Brand Family Calbiochem®
SynonymsDT-3, RQIKIWFQNRRMKWKKLRKKKKKH, PKG Inhibitor VIII
References
ReferencesDostmann, W. R.G., et al. 2000. Proc. Natl. Acad. Sci. USA 97, 14772.
Product Information
ATP CompetitiveY
FormLyophilized
FormulationSupplied as a trifluoroacetate salt.
Hill FormulaC₁₅₂H₂₅₈N₅₂O₂₈S
Chemical formulaC₁₅₂H₂₅₈N₅₂O₂₈S
Hygroscopic Hygroscopic
ReversibleY
Quality LevelMQ100
Applications
Biological Information
Primary TargetPKG1α
Primary Target K<sub>i</sub>25 nM against protein kinase G Iα
Purity≥95% by HPLC
Physicochemical Information
Cell permeableY
Peptide SequenceH-Arg-Gln-Ile-Lys-Ile-Trp-Phe-Gln-Asn-Arg-Arg-Met-Lys-Trp-Lys-Lys-Leu-Arg-Lys-Lys-Lys-Lys-Lys-His-OH
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 2 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
370655-1MG 04055977191653

Documentation

PKG Iα Inhibitor, Cell-Permeable - Calbiochem MSDS

Title

Safety Data Sheet (SDS) 

PKG Iα Inhibitor, Cell-Permeable - Calbiochem Certificates of Analysis

TitleLot Number
370655

References

Reference overview
Dostmann, W. R.G., et al. 2000. Proc. Natl. Acad. Sci. USA 97, 14772.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision11-January-2010 RFH
SynonymsDT-3, RQIKIWFQNRRMKWKKLRKKKKKH, PKG Inhibitor VIII
DescriptionA highly potent, reversible, and substrate competitive membrane-permeable peptide that selectively inhibits protein kinase G Iα (PKG Iα) (Ki = 25 nM). Inhibitor peptide is fused to the Drosophila Antennapedia homeo domain peptide to allow membrane permeability. Shown to efficiently cross the membrane of arterial smooth muscle cells and inhibit nitric oxide-induced (NO-induced) vasodilation (EC50 = 47 µM). Inhibits protein kinase A (PKA) activity only at much higher concentrations (Ki = 493 µM). The carrier peptide is also available under Cat. no. 287895.
FormLyophilized
FormulationSupplied as a trifluoroacetate salt.
Intert gas (Yes/No) Packaged under inert gas
Chemical formulaC₁₅₂H₂₅₈N₅₂O₂₈S
Peptide SequenceH-Arg-Gln-Ile-Lys-Ile-Trp-Phe-Gln-Asn-Arg-Arg-Met-Lys-Trp-Lys-Lys-Leu-Arg-Lys-Lys-Lys-Lys-Lys-His-OH
Purity≥95% by HPLC
SolubilityDMSO (10 mg/ml)
Storage -20°C
Hygroscopic
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 2 months at -20°C.
Toxicity Standard Handling
ReferencesDostmann, W. R.G., et al. 2000. Proc. Natl. Acad. Sci. USA 97, 14772.