Millipore Sigma Vibrant Logo
Attention: We have moved. Merck Millipore products are no longer available for purchase on MerckMillipore.com.Learn More

526520 PIM1 Inhibitor II

PIM1 Inhibitor II MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 3-Cyano-4-phenyl-6-(3-bromo-6-hydroxy)phenyl-2(1H)-pyridone, 2-Hydroxy-3-cyano-4-phenyl-6-(3-bromo-6-hydroxyphenyl)pyridine

Primary Target: PIM1
526520
  
Purchase on Sigma-Aldrich

Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
491871-58-0C₁₈H₁₁BrN₂O₂
Description
Overview

This product has been discontinued.



A pyridone compound that acts as an ATP-competitive inhibitor of PIM1 kinase (IC50 = 50 nM) with excellent selectivity over PIM2 and MEK1/2 (IC50 > 20 µM).
Catalogue Number526520
Brand Family Calbiochem®
Synonyms3-Cyano-4-phenyl-6-(3-bromo-6-hydroxy)phenyl-2(1H)-pyridone, 2-Hydroxy-3-cyano-4-phenyl-6-(3-bromo-6-hydroxyphenyl)pyridine
References
ReferencesCheney, I. W., et al. 2007. Bioorg. Med. Chem. Lett. 17, 1679.
Product Information
CAS number491871-58-0
ATP CompetitiveY
FormYellow solid
Hill FormulaC₁₈H₁₁BrN₂O₂
Chemical formulaC₁₈H₁₁BrN₂O₂
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetPIM1
Primary Target IC<sub>50</sub>50 nM against PIM1 kinase
Purity≥90% by HPLC
Physicochemical Information
Cell permeableN
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
526520 0

Documentation

PIM1 Inhibitor II MSDS

Title

Safety Data Sheet (SDS) 

PIM1 Inhibitor II Certificates of Analysis

TitleLot Number
526520

References

Reference overview
Cheney, I. W., et al. 2007. Bioorg. Med. Chem. Lett. 17, 1679.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision18-April-2011 RFH
Synonyms3-Cyano-4-phenyl-6-(3-bromo-6-hydroxy)phenyl-2(1H)-pyridone, 2-Hydroxy-3-cyano-4-phenyl-6-(3-bromo-6-hydroxyphenyl)pyridine
DescriptionA pyridone compound that acts as an ATP-competitive inhibitor of PIM1 kinase (IC50 = 50 nM) with excellent selectivity over PIM2 and MEK1/2 (IC50 >20 µM).
FormYellow solid
Intert gas (Yes/No) Packaged under inert gas
CAS number491871-58-0
Chemical formulaC₁₈H₁₁BrN₂O₂
Structure formulaStructure formula
Purity≥90% by HPLC
SolubilityDMSO (10 mg/ml)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity Standard Handling
ReferencesCheney, I. W., et al. 2007. Bioorg. Med. Chem. Lett. 17, 1679.