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14-558M PI3 Kinase (p120γ), 250 µg

N-terminal His6-tagged recombinant full-length human PI 3-kinase (p120γ). For use in Kinase Assays.

PI3 Kinase (p120γ), 250 µg MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
14-558M
250 µg  Also available in 20 μg size (cat#14-558) and in bulk (cat# 14-558-K).
Purchase on Sigma-Aldrich

Overview

Replacement Information
Description
Catalogue Number14-558M
Brand Family Upstate
Trade Name
  • Upstate
DescriptionPI3 Kinase (p120γ), 250 µg
OverviewN-terminal His6-tagged recombinant full-length human PI 3-kinase (p120γ).
References
Product Information
Quality LevelMQ100
Applications
ApplicationN-terminal His6-tagged recombinant full-length human PI 3-kinase (p120γ). For use in Kinase Assays.
Key Applications
  • Kinase Assay
Biological Information
SourceExpressed by baculovirus in Sf21 insect cells
Specific ActivityFor Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
Entrez Gene Number
Entrez Gene SummaryThis gene encodes a protein that belongs to the pi3/pi4-kinase family of proteins. The gene product is an enzyme that phosphorylates phosphoinositides on the 3-hydroxyl group of the inositol ring. It is an important modulator of extracellular signals, including those elicited by E-cadherin-mediated cell-cell adhesion, which plays an important role in maintenance of the structural and functional integrity of epithelia. In addition to its role in promoting assembly of adherens junctions, the protein is thought to play a pivotal role in the regulation of cytotoxicity in NK cells. The gene is located in a commonly deleted segment of chromosome 7 previously identified in myeloid leukemias.
Gene Symbol
  • PIK3CG
  • p110-gamma
  • PI3-kinase
  • PIK3
  • PI3K
  • PI3Kgamma
  • PTDINS-3-kinase
  • PI3CG
  • p120-PI3K
Protein TargetPI3Kγ
Purification MethodNi2+/NTA-agarose
Target Sub-FamilyPI3K/PI4K
UniProt Number
UniProt SummaryFUNCTION: SwissProt: P48736 # 3-phosphorylates the cellular phosphoinositide PtdIns- 4,5-biphosphate (PtdIns(4,5)P2) to produce PtdIns-3, 4,5- triiphosphate (PtdIns(3,4,5)P3). Links G-protein coupled receptor activation to the secondary messenger PtdIns(3,4,5)P3 production.
SIZE: 1102 amino acids; 126454 Da
SUBUNIT: Heterodimer of a catalytic subunit (PIK3CG/p120) and a regulatory (PIK3R5a/p101) subunit.
TISSUE SPECIFICITY: Pancreas, skeletal muscle, liver and heart.
SIMILARITY: SwissProt: P48736 ## Belongs to the PI3/PI4-kinase family. & Contains 1 PI3K/PI4K domain.
Molecular Weight130kDa
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality AssuranceRoutinely evaluated in the PIProfiler.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions6 months at -70°C
Packaging Information
Material Size250 µg
Material PackageAlso available in 20 μg size (cat#14-558) and in bulk (cat# 14-558-K).
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
14-558M 04053252621505

Related Products & Applications

Alternative Packsize

Catalogue Number Description
14-558 PI3 Kinase (p120γ), 20 µg

Product Families

Kinase & Phosphatase Products

Millipore offers a large portfolio of Kinases, Phophatases, Substrates, Inhibitors, Kits, reagents & tools for Signaling research. See below for a list of these products, in multiple pack sizes.
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Categories

Life Science Research > Proteins and Enzymes > Purified Kinases
Life Science Research > Drug Discovery and Development > Kinase & Phosphatase Screening > Purified Kinases