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528113 PI 3-Kβ Inhibitor VI, TGX-221 - CAS 663619-89-4 - Calbiochem

PI 3-Kβ Inhibitor VI, TGX-221 - CAS 663619-89-4 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: (±)-7-Methyl-2-(morpholin-4-yl)-9-(1-phenylaminoethyl)-pyrido[1,2-a]-pyrimidin-4-one, PI 3-K Inhibitor VI

Primary Target: PI 3-Kβ
528113
  
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
663619-89-4C₂₁H₂₄N₄O₂
Description
Overview

This product has been discontinued.



A cell-permeable morpholino-pyrimidinone compound that acts as a reversible, ATP-competitive, selective, and highly potent inhibitor of PI 3-Kβ (IC50 = 0.005, 0.1, 5, and ≥3.5 µM for -β, -δ, -α and -γ isoforms, respectively) with little activity against a panel of 15 commonly studied protein kinases even at concentrations as high as 10.0 µM. An excellent tool for studying p110β-dependent responses both in cells in vitro and in animals in vivo.
Catalogue Number528113
Brand Family Calbiochem®
Synonyms(±)-7-Methyl-2-(morpholin-4-yl)-9-(1-phenylaminoethyl)-pyrido[1,2-a]-pyrimidin-4-one, PI 3-K Inhibitor VI
References
ReferencesChaussade, C., et al. 2007. Biochem. J. 404, 449.
Cosemans, J.M, et al. 2006. Blood 108, 3045.
Condliffe, A.M., et al. 2005. Blood 106, 1432.
Jackson, S.P., et al. 2005. Nat. Med. 11, 507.
Product Information
CAS number663619-89-4
ATP CompetitiveY
FormWhite solid
Hill FormulaC₂₁H₂₄N₄O₂
Chemical formulaC₂₁H₂₄N₄O₂
ReversibleY
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetPI 3-Kβ
Primary Target IC<sub>50</sub>0.005, 0.1, 5, and ≥3.5 µM for -β, -δ, -α and -γ isoforms, respectively
Purity≥97% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
528113 0

Documentation

PI 3-Kβ Inhibitor VI, TGX-221 - CAS 663619-89-4 - Calbiochem MSDS

Title

Safety Data Sheet (SDS) 

PI 3-Kβ Inhibitor VI, TGX-221 - CAS 663619-89-4 - Calbiochem Certificates of Analysis

TitleLot Number
528113

References

Reference overview
Chaussade, C., et al. 2007. Biochem. J. 404, 449.
Cosemans, J.M, et al. 2006. Blood 108, 3045.
Condliffe, A.M., et al. 2005. Blood 106, 1432.
Jackson, S.P., et al. 2005. Nat. Med. 11, 507.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision17-January-2008 JSW
Synonyms(±)-7-Methyl-2-(morpholin-4-yl)-9-(1-phenylaminoethyl)-pyrido[1,2-a]-pyrimidin-4-one, PI 3-K Inhibitor VI
DescriptionA cell-permeable morpholino-pyrimidinone compound that acts as a reversible, ATP-competitive, selective, and highly potent inhibitor of PI 3-Kβ (IC50 = 0.005, 0.1, 5, and ≥3.5 µM for -β, -δ, -α and -γ isoforms, respectively) with little activity against a panel of 15 commonly studied protein kinases even at concentrations as high as 10.0 µM. An excellent tool for studying p110β-dependent responses both in cells in vitro and in animals in vivo.
FormWhite solid
Intert gas (Yes/No) Packaged under inert gas
CAS number663619-89-4
Chemical formulaC₂₁H₂₄N₄O₂
Structure formulaStructure formula
Purity≥97% by HPLC
SolubilityDMSO (10 mg/ml) or Ethanol (5 mg/ml)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity Standard Handling
ReferencesChaussade, C., et al. 2007. Biochem. J. 404, 449.
Cosemans, J.M, et al. 2006. Blood 108, 3045.
Condliffe, A.M., et al. 2005. Blood 106, 1432.
Jackson, S.P., et al. 2005. Nat. Med. 11, 507.