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521236 PDGFR/VEGFR2 Tyrosine Kinase Inhibitor, 5-Br SU6668 - CAS 251356-32-8 - Calbiochem

The PDGFR/VEGFR2 Tyrosine Kinase Inhibitor, 5-Br SU6668 controls the biological activity of PDGFR/VEGFR2 Tyrosine Kinase. Primarily used for Phosphorylation & Dephosphorylation applications.

PDGFR/VEGFR2 Tyrosine Kinase Inhibitor, 5-Br SU6668 - CAS 251356-32-8 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: (Z)-3-(2,4-Dimethyl-5-(2-oxo-1,2-dihydro-indol-3-ylidenemethyl-5-bromo)-1H-pyrrol-3-yl)-propionic acid, PDGFR Tyrosine Kinase Inhibitor XV, VEGFR Tyrosine Kinase Inhibitor XXIII, VEGFR2 Kinase Inhibitor XXVI

521236
  
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
251356-32-8C₁₈H₁₇BrN₂O₃
Description
Overview

This product has been discontinued.



A cell-permeable, ATP-binding pocket-targeting, 5-bromoindolinone analog of SU6668 (Cat. No. 521235) that is equally potent as SU6668 in inhibiting PDGFR (IC50 = 60 nM against PDGFRβ), while exhibiting more enhanced activity against VEGFR2 and FGFR1 (IC50 = 1.73 and 2.05 µM, respectively) in cell-free kinase assays. Inhibits cell proliferation mediated by VEGF, FGF, and PDGFβ, but is of little effect against EGF-mediated cell proliferation or EGFR in vitro kinase activity.
Catalogue Number521236
Brand Family Calbiochem®
Synonyms(Z)-3-(2,4-Dimethyl-5-(2-oxo-1,2-dihydro-indol-3-ylidenemethyl-5-bromo)-1H-pyrrol-3-yl)-propionic acid, PDGFR Tyrosine Kinase Inhibitor XV, VEGFR Tyrosine Kinase Inhibitor XXIII, VEGFR2 Kinase Inhibitor XXVI
References
ReferencesSun, L. et al. 1999. J. Med. Chem. 42, 5120.
Product Information
CAS number251356-32-8
FormOrange solid
Hill FormulaC₁₈H₁₇BrN₂O₃
Chemical formulaC₁₈H₁₇BrN₂O₃
Structure formula ImageStructure formula Image
Applications
Biological Information
Purity≥97% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
R PhraseR: 22-36/37/38

Harmful if swallowed.
Irritating to eyes, respiratory system and skin.
S PhraseS: 26-36-45

In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
Wear suitable protective clothing.
In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Harmful
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
521236 0

Documentation

PDGFR/VEGFR2 Tyrosine Kinase Inhibitor, 5-Br SU6668 - CAS 251356-32-8 - Calbiochem MSDS

Title

Safety Data Sheet (SDS) 

PDGFR/VEGFR2 Tyrosine Kinase Inhibitor, 5-Br SU6668 - CAS 251356-32-8 - Calbiochem Certificates of Analysis

TitleLot Number
521236

References

Reference overview
Sun, L. et al. 1999. J. Med. Chem. 42, 5120.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision04-May-2011 RFH
Synonyms(Z)-3-(2,4-Dimethyl-5-(2-oxo-1,2-dihydro-indol-3-ylidenemethyl-5-bromo)-1H-pyrrol-3-yl)-propionic acid, PDGFR Tyrosine Kinase Inhibitor XV, VEGFR Tyrosine Kinase Inhibitor XXIII, VEGFR2 Kinase Inhibitor XXVI
DescriptionA cell-permeable, ATP-binding pocket-targeting, 5-bromoindolinone analog of SU6668 (Cat. No. 521235) that is equally potent as SU6668 in inhibiting PDGFR (IC50 = 60 nM against PDGFRβ), while exhibiting more enhanced activity against VEGFR2 and FGFR1 (IC50 = 1.73 and 2.05 µM, respectively) in cell-free kinase assays. Inhibits cell proliferation mediated by VEGF, FGF, and PDGFβ, but is of little effect against EGF-mediated cell proliferation or EGFR in vitro kinase activity.
FormOrange solid
Intert gas (Yes/No) Packaged under inert gas
CAS number251356-32-8
Chemical formulaC₁₈H₁₇BrN₂O₃
Structure formulaStructure formula
Purity≥97% by HPLC
SolubilityDMSO (25 mg/ml)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Harmful
ReferencesSun, L. et al. 1999. J. Med. Chem. 42, 5120.