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513020 PD 145065 - CAS 153049-49-1 - Calbiochem

A highly potent but non-selective endothelin receptor antagonist [IC₅₀= 4 nM for the ETA receptor (rabbit renal artery vascular smooth muscle cells); IC₅₀ = 15 nM for the ETB receptor (rat cerebellum)].

PD 145065 - CAS 153049-49-1 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Primary Target: Endothelin receptor antagonist
513020
  
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
153049-49-1C₅₂H₆₃N₇O₁₀ · 2Na
Description
Overview

This product has been discontinued.



A highly potent but non-selective endothelin receptor antagonist [IC50 = 4 nM for the ETA receptor (rabbit renal artery vascular smooth muscle cells); IC50 = 15 nM for the ETB receptor (rat cerebellum)].
Catalogue Number513020
Brand Family Calbiochem®
References
ReferencesHan, H.K., et al. 1998. Life Sci. 63, 1599.
Allcock, G.H., et al. 1995. Br. J. Pharmacol. 116, 2482.
Wellings, R.P., et al. 1994. Eur. J. Pharmacol. 256, 201.
Cody, W.L., et al. 1993. Med. Chem. Res. 3, 154.
Doherty, A.M., et al. 1993. J. Cardiovasc. Pharmacol. 22, S98 (Suppl.).
Product Information
CAS number153049-49-1
ATP CompetitiveN
FormWhite solid
Hill FormulaC₅₂H₆₃N₇O₁₀ · 2Na
Chemical formulaC₅₂H₆₃N₇O₁₀ · 2Na
ReversibleN
Quality LevelMQ100
Applications
Biological Information
Primary TargetEndothelin receptor antagonist
Primary Target IC<sub>50</sub>4 nM against endothelin receptor (ETA receptor) in rabbit renal artery vascular smooth muscle cells; 15 nM for the ETB receptor (rat cerebellum)
Purity≥98% by HPLC
Physicochemical Information
Cell permeableN
Peptide SequenceAc-D-Bhg-Leu-Asp-Ile-Ile-Trp-OH (Bhg = 5H-dibenzo[a,d]cycloheptene-5-glycine)
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C) for long-term storage. Stock solutions are stable for up to 4 months at -20°C. Avoid freeze/thaw cycles of solutions.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
513020 0

Documentation

PD 145065 - CAS 153049-49-1 - Calbiochem MSDS

Title

Safety Data Sheet (SDS) 

PD 145065 - CAS 153049-49-1 - Calbiochem Certificates of Analysis

TitleLot Number
513020

References

Reference overview
Han, H.K., et al. 1998. Life Sci. 63, 1599.
Allcock, G.H., et al. 1995. Br. J. Pharmacol. 116, 2482.
Wellings, R.P., et al. 1994. Eur. J. Pharmacol. 256, 201.
Cody, W.L., et al. 1993. Med. Chem. Res. 3, 154.
Doherty, A.M., et al. 1993. J. Cardiovasc. Pharmacol. 22, S98 (Suppl.).
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision19-August-2008 RFH
DescriptionA highly potent but non-selective endothelin receptor antagonist [IC50 = 4 nM for the ETA receptor (rabbit renal artery vascular smooth muscle cells); IC50 = 15 nM for ETB receptor (rat cerebellum)].
FormWhite solid
CAS number153049-49-1
Chemical formulaC₅₂H₆₃N₇O₁₀ · 2Na
Peptide SequenceAc-D-Bhg-Leu-Asp-Ile-Ile-Trp-OH (Bhg = 5H-dibenzo[a,d]cycloheptene-5-glycine)
Purity≥98% by HPLC
SolubilityPhosphate buffer, pH 7.5 (1 mg/ml)
Storage +2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C) for long-term storage. Stock solutions are stable for up to 4 months at -20°C. Avoid freeze/thaw cycles of solutions.
Toxicity Standard Handling
ReferencesHan, H.K., et al. 1998. Life Sci. 63, 1599.
Allcock, G.H., et al. 1995. Br. J. Pharmacol. 116, 2482.
Wellings, R.P., et al. 1994. Eur. J. Pharmacol. 256, 201.
Cody, W.L., et al. 1993. Med. Chem. Res. 3, 154.
Doherty, A.M., et al. 1993. J. Cardiovasc. Pharmacol. 22, S98 (Suppl.).