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487928 Nocodazole - CAS 31430-18-9 - Calbiochem

Nocodazole, CAS 31430-18-9, is a highly specific anti-microtubular agent that promotes tubulin depolymerization and inhibits mitosis.

Nocodazole - CAS 31430-18-9 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: R17934, Methyl-[5-(2-thienylcarbonyl)-1H-benzimidazol-2-yl]-carbamate

Primary Target: Promotes tubulin depolymerization
487928
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
31430-18-9C₁₄H₁₁N₃O₃S

Products

Catalogue NumberPackaging Qty/Pack
487928-10MG Plastová ampulka 10 mg
Description
OverviewInhibitor of mitosis. Has highly specific antimicrotubular activity for mammalian cells in culture. Promotes tubulin depolymerization. Also available as a 50 mM solution in DMSO (Cat. No. 487929).
Catalogue Number487928
Brand Family Calbiochem®
SynonymsR17934, Methyl-[5-(2-thienylcarbonyl)-1H-benzimidazol-2-yl]-carbamate
References
ReferencesPark, H., et al. 2011. Chem. Med. Chem. in press.
Bunz, F., et al. 1998. Science 282, 1497.
Fleischman, L.F., et al. 1993. Oncogene 8, 771.
Pomies, P., and Block, M.R. 1992. Biochem. Biophys. Res. Commun. 189, 1429.
Rennison, M.E., et al. 1992. J. Cell Sci. 102, 239.
Thyberg, J., and Moskalewski, S. 1992. J. Cell Sci. 103, 1167.
Product Information
CAS number31430-18-9
ATP CompetitiveN
FormPale yellow solid
Hill FormulaC₁₄H₁₁N₃O₃S
Chemical formulaC₁₄H₁₁N₃O₃S
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
ApplicationNocodazole, CAS 31430-18-9, is a highly specific anti-microtubular agent that promotes tubulin depolymerization and inhibits mitosis.
Biological Information
Primary TargetPromotes tubulin depolymerization
Purity≥99% by HPLC
Physicochemical Information
Cell permeableN
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
RTECSDD6521000
Safety Information
R PhraseR: 40-63

Limited evidence of a carcinogenic effect.
Possible risk of harm to the unborn child.
S PhraseS: 36

Wear suitable protective clothing.
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Carcinogenic / Teratogenic
Storage +15°C to +30°C
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C) for long-term storage or refrigerate (4°C) for short-term storage. Stock solutions are stable for up to 1 week at 4°C or for up to 1 year at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
487928-10MG 04055977200386

Documentation

Nocodazole - CAS 31430-18-9 - Calbiochem MSDS

Title

Safety Data Sheet (SDS) 

Nocodazole - CAS 31430-18-9 - Calbiochem Certificates of Analysis

TitleLot Number
487928

References

Reference overview
Park, H., et al. 2011. Chem. Med. Chem. in press.
Bunz, F., et al. 1998. Science 282, 1497.
Fleischman, L.F., et al. 1993. Oncogene 8, 771.
Pomies, P., and Block, M.R. 1992. Biochem. Biophys. Res. Commun. 189, 1429.
Rennison, M.E., et al. 1992. J. Cell Sci. 102, 239.
Thyberg, J., and Moskalewski, S. 1992. J. Cell Sci. 103, 1167.

Citations

Title
  • Meng Qiao, et al. (2006) Cell cycle-dependent phosphorylation of the RUNX2 transcription factor by cdc2 regulates endothelial cell proliferation. Journal of Biological Chemistry 281, 7118-7128.
    		•
    Data Sheet

    Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

    Revision19-June-2012 JSW
    SynonymsR17934, Methyl-[5-(2-thienylcarbonyl)-1H-benzimidazol-2-yl]-carbamate
    DescriptionInhibitor of mitosis. Has highly specific antimicrotubular activity for mammalian cells in culture. Promotes tubulin depolymerization. Also acts as a high-affinity ligand for the cancer-related kinases ABL, c-KIT, BRAF, and MEK (Kd < 2 µM).
    FormPale yellow solid
    CAS number31430-18-9
    RTECSDD6521000
    Chemical formulaC₁₄H₁₁N₃O₃S
    Structure formulaStructure formula
    Purity≥99% by HPLC
    SolubilityDMSO (5 mg/ml)
    Storage +15°C to +30°C
    Do Not Freeze Ok to freeze
    Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C) for long-term storage or refrigerate (4°C) for short-term storage. Stock solutions are stable for up to 1 week at 4°C or for up to 1 year at -20°C.
    Toxicity Carcinogenic / Teratogenic
    ReferencesPark, H., et al. 2011. Chem. Med. Chem. in press.
    Bunz, F., et al. 1998. Science 282, 1497.
    Fleischman, L.F., et al. 1993. Oncogene 8, 771.
    Pomies, P., and Block, M.R. 1992. Biochem. Biophys. Res. Commun. 189, 1429.
    Rennison, M.E., et al. 1992. J. Cell Sci. 102, 239.
    Thyberg, J., and Moskalewski, S. 1992. J. Cell Sci. 103, 1167.
    Citation
  • Meng Qiao, et al. (2006) Cell cycle-dependent phosphorylation of the RUNX2 transcription factor by cdc2 regulates endothelial cell proliferation. Journal of Biological Chemistry 281, 7118-7128.
    		•