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481990 Nigericin, Sodium Salt, Streptomyces hygroscopicus - CAS 28643-80-3 - Calbiochem

Nigericin, Sodium Salt, Streptomyces hygroscopicus, CAS 28643-80-3, is an antibiotic K+ ionophore that disrupts the membrane potential and stimulates ATPase activity in mitochondria.

Nigericin, Sodium Salt, Streptomyces hygroscopicus - CAS 28643-80-3 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Antibiotic K178

481990
  
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
28643-80-3C₄₀H₆₇O₁₁ . Na
Description
OverviewDisrupts the membrane potential and stimulates ATPase activity in mitochondria. Transports monovalent cations across membranes with the following specificity: K+>Rb+>Cs+>>Na+.
Catalogue Number481990
Brand Family Calbiochem®
SynonymsAntibiotic K178
References
ReferencesMoriyama, Y., et al. 1994. J. Biochem. 115, 213.
Eytan, G.D., et al. 1990. J. Biol. Chem. 265, 12949.
Alonso, M.A., and Carrasco, L. 1981. FEBS Lett. 127, 112.
Product Information
CAS number28643-80-3
ATP CompetitiveN
FormLyophilized
Hill FormulaC₄₀H₆₇O₁₁ . Na
Chemical formulaC₄₀H₆₇O₁₁ . Na
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
ApplicationNigericin, Sodium Salt, Streptomyces hygroscopicus, CAS 28643-80-3, is an antibiotic K+ ionophore that disrupts the membrane potential and stimulates ATPase activity in mitochondria.
Biological Information
Primary TargetDisrupts the membrane potential and stimulates ATPase activity in mitochondria.
Purity≥98% by TLC
Physicochemical Information
Cell permeableN
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
RTECSQT6825000
Safety Information
R PhraseR: 23/24/25-36/37/38

Toxic by inhalation, in contact with skin and if swallowed.
Irritating to eyes, respiratory system and skin.
S PhraseS: 22-36/37/39-45

Do not breathe dust.
Wear suitable protective clothing, gloves and eye/face protection.
In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Toxic
Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Storage +2°C to +8°C
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze. Stock solutions are stable for 1 month at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
481990 0

Documentation

Nigericin, Sodium Salt, Streptomyces hygroscopicus - CAS 28643-80-3 - Calbiochem MSDS

Title

Safety Data Sheet (SDS) 

Nigericin, Sodium Salt, Streptomyces hygroscopicus - CAS 28643-80-3 - Calbiochem Certificates of Analysis

TitleLot Number
481990

References

Reference overview
Moriyama, Y., et al. 1994. J. Biochem. 115, 213.
Eytan, G.D., et al. 1990. J. Biol. Chem. 265, 12949.
Alonso, M.A., and Carrasco, L. 1981. FEBS Lett. 127, 112.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision15-May-2008 RFH
SynonymsAntibiotic K178
DescriptionA monocarboxylate that catalyzes the electroneutral exchange of an alkali metal for H+ (antiport). Transports monovalent cations across membranes with the following specificities: K+>Rb+>Cs+>>Na+. An antibiotic that kills bacteria by facilitating the diffusion of ions across membranes. Disrupts the membrane potential and stimulates mitochondrial ATPase activity.
FormLyophilized
CAS number28643-80-3
RTECSQT6825000
Chemical formulaC₄₀H₆₇O₁₁ . Na
Structure formulaStructure formula
Purity≥98% by TLC
SolubilityCHCl₃, ethanol, or ethyl acetate
Storage +2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze. Stock solutions are stable for 1 month at -20°C.
Toxicity Toxic
Merck USA index14, 6541
ReferencesMoriyama, Y., et al. 1994. J. Biochem. 115, 213.
Eytan, G.D., et al. 1990. J. Biol. Chem. 265, 12949.
Alonso, M.A., and Carrasco, L. 1981. FEBS Lett. 127, 112.