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533087 Niclosamide Ethanolamine - Calbiochem

Niclosamide Ethanolamine, NEN, AMPK activator

Niclosamide Ethanolamine - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: NEN

533087
  
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Overview

Replacement Information

Key Spec Table

Empirical Formula
C₁₃H₈Cl₂N₂O₄·C₂H₇NO
Description
Overview

This product has been discontinued.



A cell permeable, orally bioavailable, non-toxic salt form of niclosamide that acts as a reversible, mild uncoupler of mitochondria to reduce cellular energy efficiency and increase lipid oxidation. Also shown to reduce the mitochondrial membrane potential in live cells (~ 500 nM). Following oral uptake, it is distributed primarily in the liver. Improves glycemic control, improves insulin sensitivity,and reduces the level of glycated hemoglobin in C57BL/6J mice fed high fat diets. Retards the decline of plasma insulin level in db/db mice and improves their glycemic control. (150 mg/kg., p.o.). Activates AMPK and increases acetyl-CoA carboxylase phosphorylation, but does not affect the activity of gluconeogenic enzymes in the liver. Reported to reduce intracellular lipid accumulation in mice fed high fat diets.
Catalogue Number533087
Brand Family Calbiochem®
SynonymsNEN
References
ReferencesTao, H., et al. 2014. Nat. Med. 20, 1263.
Product Information
FormYellow solid
Hill FormulaC₁₃H₈Cl₂N₂O₄·C₂H₇NO
Chemical formulaC₁₃H₈Cl₂N₂O₄·C₂H₇NO
ReversibleY
Quality LevelMQ100
Applications
Biological Information
Purity≥98% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
533087 0

Documentation

Niclosamide Ethanolamine - Calbiochem MSDS

Title

Safety Data Sheet (SDS) 

References

Reference overview
Tao, H., et al. 2014. Nat. Med. 20, 1263.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision01-March-2016 JSW
SynonymsNEN
DescriptionA cell permeable, orally bioavailable, non-toxic salt form of niclosamide that acts as a reversible, mild uncoupler of mitochondria to reduce cellular energy efficiency and increase lipid oxidation. Also shown to reduce the mitochondrial membrane potential in live cells (~ 500 nM). Following oral uptake, it is distributed primarily in the liver. Improves glycemic control, improves insulin sensitivity,and reduces the level of glycated hemoglobin in C57BL/6J mice fed high fat diets. Retards the decline of plasma insulin level in db/db mice and improves their glycemic control. (150 mg/kg., p.o.). Activates AMPK and increases acetyl-CoA carboxylase phosphorylation, but does not affect the activity of gluconeogenic enzymes in the liver. Reported to reduce intracellular lipid accumulation in mice fed high fat diets.
FormYellow solid
Intert gas (Yes/No) Packaged under inert gas
Chemical formulaC₁₃H₈Cl₂N₂O₄·C₂H₇NO
Purity≥98% by HPLC
SolubilityDMSO (50 mg/ml)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesTao, H., et al. 2014. Nat. Med. 20, 1263.