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483125 NG-Nitro-L-arginine Methyl Ester, Hydrochloride - CAS 51298-62-5 - Calbiochem

Cell permeable. More soluble analog of arginine and a competitive, slowly reversible inhibitor of eNOS (IC₅₀ = 500 nM). Causes a prolonged inhibition of acetylcholine-induced relaxation of rat aortic rings (IC₅₀ = 400 nM).

NG-Nitro-L-arginine Methyl Ester, Hydrochloride - CAS 51298-62-5 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Nω-NO₂-L-Arg-OMe, NG-NO₂-L-Arg-OMe, L-NAME, HCl

Primary Target: eNOS
483125
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
51298-62-5C₇H₁₅N₅O₄ . HCl

Products

Catalogue NumberPackaging Qty/Pack
483125-100MG Sklená flaša 100 mg
Description
OverviewCell permeable. More soluble analog of arginine and a competitive, slowly reversible inhibitor of eNOS (IC50 = 500 nM). Causes a prolonged inhibition of acetylcholine-induced relaxation of rat aortic rings (IC50 = 400 nM).
Catalogue Number483125
Brand Family Calbiochem®
SynonymsNω-NO₂-L-Arg-OMe, NG-NO₂-L-Arg-OMe, L-NAME, HCl
References
ReferencesBaylis, C., et al. 1995. J. Pharmacol. Exp. Ther. 274, 1135.
Dawson, V.L., et al. 1991. Proc. Natl. Acad. Sci. USA 88, 6368.
Kubes, P., et al. 1991. Proc. Natl. Acad. Sci. USA 88, 4651.
Moncada, S., et al. 1991. Pharmacol. Rev. 43, 109.
Moore, P.K., et al. 1990. Br. J. Pharmacol. 99, 408.
Product Information
CAS number51298-62-5
ATP CompetitiveN
FormWhite to off-white solid
Hill FormulaC₇H₁₅N₅O₄ . HCl
Chemical formulaC₇H₁₅N₅O₄ . HCl
Hygroscopic Hygroscopic
ReversibleY
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargeteNOS
Primary Target IC<sub>50</sub>500 nM against eNOS
Purity≥98% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Blue Ice Only
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 4 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
483125-100MG 04055977200652

Documentation

NG-Nitro-L-arginine Methyl Ester, Hydrochloride - CAS 51298-62-5 - Calbiochem MSDS

Title

Safety Data Sheet (SDS) 

NG-Nitro-L-arginine Methyl Ester, Hydrochloride - CAS 51298-62-5 - Calbiochem Certificates of Analysis

TitleLot Number
483125

References

Reference overview
Baylis, C., et al. 1995. J. Pharmacol. Exp. Ther. 274, 1135.
Dawson, V.L., et al. 1991. Proc. Natl. Acad. Sci. USA 88, 6368.
Kubes, P., et al. 1991. Proc. Natl. Acad. Sci. USA 88, 4651.
Moncada, S., et al. 1991. Pharmacol. Rev. 43, 109.
Moore, P.K., et al. 1990. Br. J. Pharmacol. 99, 408.

Brochure

Title
Pathways and Biomarkers of Oxidative Stress
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision29-November-2010 RFH
SynonymsNω-NO₂-L-Arg-OMe, NG-NO₂-L-Arg-OMe, L-NAME, HCl
DescriptionMore soluble analog of arginine and a competitive, slowly reversible inhibitor of endothelial nitric oxide synthase (IC50 = 500 nM). Causes a prolonged inhibition of acetylcholine-induced relaxation of rat aortic rings (IC50 = 400 nM).
FormWhite to off-white solid
Intert gas (Yes/No) Packaged under inert gas
CAS number51298-62-5
Chemical formulaC₇H₁₅N₅O₄ . HCl
Structure formulaStructure formula
Purity≥98% by HPLC
SolubilityH₂O (50 mg/ml)
Storage Protect from light
-20°C
Hygroscopic
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 4 months at -20°C.
Toxicity Standard Handling
ReferencesBaylis, C., et al. 1995. J. Pharmacol. Exp. Ther. 274, 1135.
Dawson, V.L., et al. 1991. Proc. Natl. Acad. Sci. USA 88, 6368.
Kubes, P., et al. 1991. Proc. Natl. Acad. Sci. USA 88, 4651.
Moncada, S., et al. 1991. Pharmacol. Rev. 43, 109.
Moore, P.K., et al. 1990. Br. J. Pharmacol. 99, 408.