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MAC131 Mouse anti-Camelid IgG2/3 (heavy chain) Antibody, clone P17JE11

Mouse anti-Camelid IgG2/3 (heavy chain), clone P17JE11 detects Camelid IgG2/igG3 heavy chain. It has been tested for use in ELISA.

MAC131
100 μg  
Purchase on Sigma-Aldrich

Overview

Replacement Information
Description
Catalogue NumberMAC131
DescriptionMouse anti-Camelid IgG2/3 (heavy chain) Antibody, clone P17JE11
Alternate Names
  • HCAbs
  • Camelid antibody
Background InformationCamelidae family that includes camels and llamas are the only mammals reported to have heavy-chain (IgG-like) antibodies. Camelids produce conventional antibodies, but they also produce antibodies that do not associate with light chains. They produce functional antibodies devoid of light chains of which the single N-terminal domain is fully capable of antigen binding. Their VHH domain is located on a single stretch of amino acids and retains its antigen-recognition capability. Their heavy chains are devoid of the CH1 domain and have modified VH domain. Camelid heavy-chain antibodies (HCAbs) comprise about 50% of serum IgG in Llama and about 75% in Camelus species. HCAbs exhibit a molecular mass of about 100 kDa, which is smaller than conventional IgG1 and allows it to bind epitopes that may not be accessible to conventional antibodies. Also, the smaller size and single domain make it easier to transform them into bacterial cells for larger production needs. HCAbs are reported to display similar specificities, but are more robust in some cases. (Ref.: Daley LP et al. (2010). Clin. Vaccine Immunol. 17(2); 239-246; Harmsen, MM., and De Haard, HJ (2007) Appl Microbiol Biotechnol 77(1):13-22).
References
Product Information
FormatPurified
PresentationPurified mouse monoclonal antibody IgG1 in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Quality LevelMQ100
Applications
ApplicationMouse anti-Camelid IgG2/3 (heavy chain), clone P17JE11 detects Camelid IgG2/igG3 heavy chain. It has been tested for use in ELISA.
Key Applications
  • ELISA
Biological Information
ImmunogenCamelid heavy-chain immunoglobulin G (clgG2/3).
CloneP17JE11
ConcentrationPlease refer to lot specific datasheet.
HostMouse
SpecificityClone P17JE11 detects Camelid IgG2/igG3 heavy chain. Displays trivial to none reactivity with other species.
IsotypeIgG1κ
Species Reactivity
  • Camelid
Species Reactivity NoteCamel, Llama
Antibody TypeMonoclonal Antibody
Purification MethodProtein G purified
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality AssuranceEvaluated by ELISA in IgG as tested in various species.

ELISA Analysis: 2 µg/mL of this antibody detected Camelid IgG2/3 (heavy chain).
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
Packaging Information
Material Size100 μg
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
MAC131 04054839330704

Documentation

Mouse anti-Camelid IgG2/3 (heavy chain) Antibody, clone P17JE11 MSDS

Title

Safety Data Sheet (SDS) 

Mouse anti-Camelid IgG2/3 (heavy chain) Antibody, clone P17JE11 Certificates of Analysis

TitleLot Number
Mouse anti-Camelid IgG2/3 (heavy chain), clone P17JE11 - 3172379 3172379
Mouse anti-Camelid IgG2/3 (heavy chain), clone P17JE11 - 3698071 3698071
Mouse anti-Camelid IgG2/3 (heavy chain), clone P17JE11 - 4101376 4101376
Mouse anti-Camelid IgG2/3 (heavy chain), clone P17JE11 Monoclonal Antibody 3069669
Mouse anti-Camelid IgG2/3 (heavy chain), clone P17JE11 Monoclonal Antibody Q2914127
Mouse anti-Camelid IgG2/3 (heavy chain), clone P17JE11 Monoclonal Antibody 3102325

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