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505984 Mitochondrial Content Inducer, BRD6897 - CAS 618395-82-7 - Calbiochem

Mitochondrial Content Inducer, BRD6897 - CAS 618395-82-7 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: BRD 6897, 5,6-Dimethyl-2-(2-(2-methyl-1H-indol-3-yl)-2-oxoethylthio)-3-phenylthieno[2,3-d]pyrimidin-4(3H)-one

505984
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
618395-82-7C₂₅H₂₁N₃O₂S₂

Products

Catalogue NumberPackaging Qty/Pack
5.05984.0001 Sklená flaša 25 mg
Description
OverviewA cell-permeable indolylphenylthienopyrimidinone compound that increases mitochondrial content without affecting the cell size (~10 µM). Reduces mitochondrial protein turnover without affecting any known transcriptional programs of mitochondrial biogenesis. Reversibly increases uncoupled respiration in non-dividing cells (~50% increase in 3T3-L1 and HUVEC at 10 µM), but appears to be toxic to dividing cells. Shown to increase the expression of mitochondrial DNA encoded oxidative phosphorylation (OxPhos) genes without affecting nuclear DNA encoded OxPhos gene expression.
Catalogue Number505984
Brand Family Calbiochem®
SynonymsBRD 6897, 5,6-Dimethyl-2-(2-(2-methyl-1H-indol-3-yl)-2-oxoethylthio)-3-phenylthieno[2,3-d]pyrimidin-4(3H)-one
References
ReferencesKitami, T., et al. 2012. PLoS ONE 7, e33755.
Product Information
CAS number618395-82-7
FormOff-white powder
Hill FormulaC₂₅H₂₁N₃O₂S₂
Chemical formulaC₂₅H₂₁N₃O₂S₂
ReversibleY
Quality LevelMQ100
Applications
Biological Information
Purity≥98% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
5.05984.0001 04055977262568

Documentation

Mitochondrial Content Inducer, BRD6897 - CAS 618395-82-7 - Calbiochem MSDS

Title

Safety Data Sheet (SDS) 

References

Reference overview
Kitami, T., et al. 2012. PLoS ONE 7, e33755.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision22-November-2013 JSW
SynonymsBRD 6897, 5,6-Dimethyl-2-(2-(2-methyl-1H-indol-3-yl)-2-oxoethylthio)-3-phenylthieno[2,3-d]pyrimidin-4(3H)-one
DescriptionA cell-permeable indolylphenylthienopyrimidinone compound that increases mitochondrial content without affecting the cell size (~10 µM). Reduces mitochondrial protein turnover without affecting any known transcriptional programs of mitochondrial biogenesis. Reversibly increases uncoupled respiration in non-dividing cells (~50% increase in 3T3-L1 and HUVEC at 10 µM), but appears to be toxic to dividing cells. Shown to increase the expression of mitochondrial DNA encoded oxidative phosphorylation (OxPhos) genes without affecting nuclear DNA encoded OxPhos gene expression.
FormOff-white powder
Intert gas (Yes/No) Packaged under inert gas
CAS number618395-82-7
Chemical formulaC₂₅H₂₁N₃O₂S₂
Purity≥98% by HPLC
SolubilityDMSO (10 mg/ml)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity Standard Handling
ReferencesKitami, T., et al. 2012. PLoS ONE 7, e33755.