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FCMAB289A4 Milli-Mark® Anti-PINK1-Alexa Fluor 488 Antibody, clone N4/49

Milli-Mark Anti-PINK1-Alexa Fluor 488 Antibody, clone N4/49 is an antibody against PINK1-Alexa Fluor 488 for use in FC.

Milli-Mark® Anti-PINK1-Alexa Fluor 488 Antibody, clone N4/49 MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Neuroscience Research Sub-Category: Neurodegenerative Diseases Gene Symbol: PINK1, PARK6, BRPK UniProt Number: Q9BXM7
FCMAB289A4
100 tests  
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Key Spec Table

Species ReactivityKey ApplicationsHostFormatAntibody Type
HFCMAlexaFluor®488Monoclonal Antibody
Description
Catalogue NumberFCMAB289A4
Trade Name
  • Milli-Mark
DescriptionMilli-Mark® Anti-PINK1-Alexa Fluor 488 Antibody, clone N4/49
Alternate Names
  • PTEN induced putative kinase 1
  • protein kinase BRPK
  • serine/threonine-protein kinase PINK1
  • PTEN-induced putative kinase protein 1
  • Parkinson disease (autosomal recessive) 6
Background InformationMutations in the PTEN-induced kinase 1 (PINK1) gene located within the PARK6 locus on chromosome 1p35-p36 have recently been identified in patients with recessive early-onset Parkinson disease. Data suggests that PINK1 may be the second most common causative gene next to parkin in parkinsonism with the recessive mode of inheritance.
References
Product Information
FormatAlexaFluor®488
Control
  • HEK293 cells
PresentationPurified mouse monoclonal IgG1k conjugated to Alexa Fluor® 488 in PBS with 0.1% sodium azide and 15 mg/mL BSA.
Quality LevelMQ100
Applications
ApplicationMilli-Mark Anti-PINK1-Alexa Fluor 488 Antibody, clone N4/49 is an antibody against PINK1-Alexa Fluor 488 for use in FC.
Key Applications
  • Flow Cytometry
Biological Information
ImmunogenRecombinant protein corresponding to human PINK1.
CloneN4/49
HostMouse
SpecificityAntibody recognizes human PINK1.
IsotypeIgG1κ
Species Reactivity
  • Human
Antibody TypeMonoclonal Antibody
Entrez Gene Number
Entrez Gene SummaryThis gene encodes a serine/threonine protein kinase that localizes to mitochondria. It is thought to protect cells from stress-induced mitochondrial dysfunction. Mutations in this gene cause one form of autosomal recessive early-onset Parkinson disease.
Gene Symbol
  • PINK1
  • PARK6
  • BRPK
Purification MethodProtein G Purified
UniProt Number
UniProt SummaryFUNCTION: Protects against mitochondrial dysfunction during cellular stress, potentially by phosphorylating mitochondrial proteins.

CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein.

COFACTOR: Magnesium.

SUBCELLULAR LOCATION: Mitochondrion outer membrane; Single-pass membrane protein.

TISSUE SPECIFICITY: Highly expressed in heart, skeletal muscle and testis, and at lower levels in brain, placenta, liver, kidney, pancreas, prostate, ovary and small intestine. Present in the embryonic testis from an early stage of development.

PTM: Autophosphorylated.

INVOLVEMENT IN DISEASE: Defects in PINK1 are the cause of Parkinson disease type 6 (PARK6) [MIM:605909]. A neurodegenerative disorder characterized by parkinsonian signs such as rigidity, resting tremor and bradykinesia. A subset of patients manifest additional symptoms including hyperreflexia, autonomic instability, dementia and psychiatric disturbances. Symptoms show diurnal fluctuation and can improve after sleep.

SEQUENCE SIMILARITIES: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.

Contains 1 protein kinase domain.
Molecular WeightUniprot describes two isoforms exist with calculated Mw of 63 and 30 kDa.
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality AssuranceEvaluated by flow cytometry using HEK293 cells.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsMaintain refrigerated at 2-8 °C protected from light in undiluted aliquots for up to 6 months from date of receipt.
Packaging Information
Material Size100 tests
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
FCMAB289A4 04053252294945

Documentation

Milli-Mark® Anti-PINK1-Alexa Fluor 488 Antibody, clone N4/49 MSDS

Title

Safety Data Sheet (SDS) 

Milli-Mark® Anti-PINK1-Alexa Fluor 488 Antibody, clone N4/49 Certificates of Analysis

TitleLot Number
Milli-Mark#174; Anti-PINK1-Alexa Fluor#174; 488, clone N4/49 - NRG1937006 NRG1937006
Milli-MarkTM Anti-PINK1-Alexa Fluor#174; 488, clone N4/49 - 2070847 2070847
Milli-MarkTM Anti-PINK1-Alexa Fluor® -2567122 2567122
Milli-MarkTM Anti-PINK1-Alexa Fluor® 488, clone N4/49 - 2329148 2329148
Milli-MarkTM Anti-PINK1-Alexa Fluor® 488, clone N4/49 - 3465946 3465946
Milli-MarkTM Anti-PINK1-Alexa Fluor® 488, clone N4/49 - 3744821 3744821
Milli-MarkTM Anti-PINK1-Alexa Fluor® 488, clone N4/49 - 3866256 3866256
Milli-MarkTM Anti-PINK1-Alexa Fluor® 488, clone N4/49 -2508537 2508537
Milli-MarkTM Anti-PINK1-Alexa Fluor® 488, clone N4/49 -2538639 2538639
Milli-MarkTM Anti-PINK1-Alexa Fluor® 488, clone N4/49 Conjugate 2952318
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