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317240 Metformin - CAS 1115-70-4 - Calbiochem

Metformin, CAS 1115-70-4, lowers blood glucose levels without stimulating insulin secretion. Stimulates AMPK leading to the reduction in acetyl-CoA carboxylase (ACC) activity.

Metformin - CAS 1115-70-4 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 1,1-Dimethylbiguanide, Hydrochloride, AMPK Signaling Activator VII

Primary Target: AMP-activated protein kinase (AMPK)
317240
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
1115-70-4C₄H₁₁N₅ • HCl

Products

Catalogue NumberPackaging Qty/Pack
317240-5GM Sklená flaša 5 gm
Description
OverviewAn antihyperglycemic agent that lowers blood glucose levels without stimulating insulin secretion, promoting weight gain or causing hypoglycemia. Reported to stimulate AMP-activated protein kinase (AMPK) leading to the reduction in acetyl-CoA carboxylase (ACC) activity and induction of fatty acid oxidation.
Catalogue Number317240
Brand Family Calbiochem®
Synonyms1,1-Dimethylbiguanide, Hydrochloride, AMPK Signaling Activator VII
References
ReferencesCleasby, M.E., et al. 2004. Diabetes 53, 3258.
Klein, J., et al. 2004. J. Endocrinol. 183, 299.
Zhou, G., et al. 2001. J. Clin. Invest. 108, 1167.
Lin, H.Z., et al. 2000. Nat. Med. 6, 998.
Product Information
CAS number1115-70-4
ATP CompetitiveN
FormWhite solid
Hill FormulaC₄H₁₁N₅ • HCl
Chemical formulaC₄H₁₁N₅ • HCl
Hygroscopic Hygroscopic
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
ApplicationMetformin, CAS 1115-70-4, lowers blood glucose levels without stimulating insulin secretion. Stimulates AMPK leading to the reduction in acetyl-CoA carboxylase (ACC) activity.
Biological Information
Primary TargetAMP-activated protein kinase (AMPK)
Purity≥97% by Titration
Physicochemical Information
Cell permeableN
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
RTECSDU1800000
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Irritant
Storage +15°C to +30°C
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
317240-5GM 04055977216196

Documentation

Metformin - CAS 1115-70-4 - Calbiochem MSDS

Title

Safety Data Sheet (SDS) 

Metformin - CAS 1115-70-4 - Calbiochem Certificates of Analysis

TitleLot Number
317240

References

Reference overview
Cleasby, M.E., et al. 2004. Diabetes 53, 3258.
Klein, J., et al. 2004. J. Endocrinol. 183, 299.
Zhou, G., et al. 2001. J. Clin. Invest. 108, 1167.
Lin, H.Z., et al. 2000. Nat. Med. 6, 998.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision01-May-2008 RFH
Synonyms1,1-Dimethylbiguanide, Hydrochloride, AMPK Signaling Activator VII
DescriptionAn anti-hyperglycemic agent that acts by lowering the hepatic output of glucose. Does not stimulate insulin secretion, promote weight gain, or cause hypoglycemia. Reported to stimulate AMP-activated protein kinase (AMPK), leading to the reduction in acetyl-CoA carboxylase (ACC) activity and induction of fatty acid oxidation.
FormWhite solid
Intert gas (Yes/No) Packaged under inert gas
CAS number1115-70-4
RTECSDU1800000
Chemical formulaC₄H₁₁N₅ • HCl
Structure formulaStructure formula
Purity≥97% by Titration
SolubilityH₂O (50 mg/ml)
Storage +15°C to +30°C
Hygroscopic
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity Irritant
Merck USA index14, 5938
ReferencesCleasby, M.E., et al. 2004. Diabetes 53, 3258.
Klein, J., et al. 2004. J. Endocrinol. 183, 299.
Zhou, G., et al. 2001. J. Clin. Invest. 108, 1167.
Lin, H.Z., et al. 2000. Nat. Med. 6, 998.