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444251 MMP-2/MMP-9 Inhibitor III - Calbiochem

The MMP-2/MMP-9 Inhibitor III controls the biological activity of MMP-2/MMP-9. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.

MMP-2/MMP-9 Inhibitor III - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Primary Target: MMP-2, MMP-9
444251
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Overview

Replacement Information

Key Spec Table

Empirical Formula
C₅₂H₇₁N₁₃O₁₄S₂

Products

Catalogue NumberPackaging Qty/Pack
444251-1MG Plastová ampulka 1 mg
Description
OverviewA hydrophobic cyclic peptide that acts as a potent inhibitor of MMP-2 and MMP-9 (IC50 = 10 µM). Inhibits the migration of human endothelial cells and tumor cells, and prevents tumor growth and invasion in animal models. Also, phage that display this peptide specifically targets angiogenic blood vessels in vivo.
Catalogue Number444251
Brand Family Calbiochem®
References
ReferencesMedina, O.P., et al. 2001. Cancer Res. 61, 3978.
Koivunen, E., et al. 1999. Nat. Biotechnology 17, 768.
Product Information
ATP CompetitiveN
DeclarationSold under license of U.S. Patent 6,624,144.
FormWhite lyophilized solid
FormulationSupplied as a trifluoroacetate salt.
Hill FormulaC₅₂H₇₁N₁₃O₁₄S₂
Chemical formulaC₅₂H₇₁N₁₃O₁₄S₂
Hygroscopic Hygroscopic
ReversibleN
Quality LevelMQ100
Applications
Biological Information
Primary TargetMMP-2, MMP-9
Primary Target IC<sub>50</sub>10 µM against MMP-2 and MMP-9
Purity≥97% by HPLC
Physicochemical Information
Cell permeableN
Peptide SequenceH-Cys¹-Thr-Thr-His-Trp-Gly-Phe-Thr-Leu-Cys¹⁰-OH (cyclic: 1→ 10)
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze at -20°C. Stock solutions are stable for up to 2 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
444251-1MG 04055977186512

Documentation

MMP-2/MMP-9 Inhibitor III - Calbiochem MSDS

Title

Safety Data Sheet (SDS) 

MMP-2/MMP-9 Inhibitor III - Calbiochem Certificates of Analysis

TitleLot Number
444251

References

Reference overview
Medina, O.P., et al. 2001. Cancer Res. 61, 3978.
Koivunen, E., et al. 1999. Nat. Biotechnology 17, 768.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision06-August-2008 RFH
DescriptionA cyclic peptide that acts as a potent inhibitor of MMP-2 (gelatinase A; IC50 = 10 µM) and MMP-9 (gelatinase B; IC50 = 10 µM). Inhibits the migration of human endothelial cells and tumor cells, and prevents tumor growth and invasion in animal models.
FormWhite lyophilized solid
FormulationSupplied as a trifluoroacetate salt.
Intert gas (Yes/No) Packaged under inert gas
Chemical formulaC₅₂H₇₁N₁₃O₁₄S₂
Peptide SequenceH-Cys¹-Thr-Thr-His-Trp-Gly-Phe-Thr-Leu-Cys¹⁰-OH (cyclic: 1→ 10)
Purity≥97% by HPLC
SolubilityH₂O (5 mg/ml)
Storage -20°C
Hygroscopic
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze at -20°C. Stock solutions are stable for up to 2 months at -20°C.
Toxicity Standard Handling
ReferencesMedina, O.P., et al. 2001. Cancer Res. 61, 3978.
Koivunen, E., et al. 1999. Nat. Biotechnology 17, 768.