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444938 MEK Inhibitor II - CAS 623163-52-0 - Calbiochem

MEK Inhibitor II - CAS 623163-52-0 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 2-Chloro-3-(N-succinimidyl)-1,4-naphthoquinone

Primary Target: MEK1
444938
  
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
623163-52-0C₁₄H₈NO₄Cl
Description
Overview

This product has been discontinued.



A cell-permeable 1,4-naphthoquinone compound that acts as potent and selective inhibitor of MEK (IC50 = 0.38 µM for MEK1). It shows little effect on PKC and PKA, and inhibits Raf1 and ERK1 only at much higher concentrations (IC50 = 34.5 and 82.9 µM, respectively).
Catalogue Number444938
Brand Family Calbiochem®
Synonyms2-Chloro-3-(N-succinimidyl)-1,4-naphthoquinone
References
ReferencesBakare, O., et al. 2003. Bioorg. Med. Chem. 11, 3165.
Product Information
CAS number623163-52-0
ATP CompetitiveN
FormYellow solid
Hill FormulaC₁₄H₈NO₄Cl
Chemical formulaC₁₄H₈NO₄Cl
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetMEK1
Primary Target IC<sub>50</sub>0.38 µM for MEK1
Purity≥97% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Carcinogenic / Teratogenic
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
444938 0

Documentation

MEK Inhibitor II - CAS 623163-52-0 - Calbiochem MSDS

Title

Safety Data Sheet (SDS) 

MEK Inhibitor II - CAS 623163-52-0 - Calbiochem Certificates of Analysis

TitleLot Number
444938

References

Reference overview
Bakare, O., et al. 2003. Bioorg. Med. Chem. 11, 3165.

Brochure

Title
Pathways and Biomarkers of Toll-like Receptor (TLR) Signaling
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision08-December-2008 RFH
Synonyms2-Chloro-3-(N-succinimidyl)-1,4-naphthoquinone
DescriptionA cell-permeable, potent, and selective inhibitor of MEK (IC50 = 380 nM for MEK1). Exhibits negligible inhibitory effects on protein kinase C (PKC) and protein kinase A (PKA). Inhibits Raf1 and ERK1 only at much higher concentrations (IC50 = 34.5 µM and 82.9 µM, respectively).
FormYellow solid
Intert gas (Yes/No) Packaged under inert gas
CAS number623163-52-0
Chemical formulaC₁₄H₈NO₄Cl
Structure formulaStructure formula
Purity≥97% by HPLC
SolubilityDMSO (10 mg/ml)
Storage Protect from light
-20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Carcinogenic / Teratogenic
ReferencesBakare, O., et al. 2003. Bioorg. Med. Chem. 11, 3165.