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440203 LY 303511 - CAS 154447-38-8 - Calbiochem

A cell-permeable negative control for the PI 3-kinase inhibitor LY 294002.

LY 303511 - CAS 154447-38-8 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 2-Piperazinyl-8-phenyl-4H-1-benzopyran-4-one, BRD2 Inhibitor V, BRD3 Inhibitor IV, BRD4 Inhibitor V

Primary Target: Negative control for the PI 3-kinase inhibitor LY 294002
440203
  
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
154447-38-8C₁₉H₁₈N₂O₂
Description
OverviewA cell-permeable negative control for the PI 3-kinase inhibitor LY 294002 (Cat. No. 440202). Contains a single atom substitution in the morpholine ring compared to LY 294002. Does not inhibit PI 3-kinase even at a concentration of 100 µM. Shown to bind to the same site as I-BET (Cat. no. 401010) and reversibly inhibit BET bromodomain proteins BRD2, BRD3 & BRD4 (IC50 ~10 µM).
Catalogue Number440203
Brand Family Calbiochem®
Synonyms2-Piperazinyl-8-phenyl-4H-1-benzopyran-4-one, BRD2 Inhibitor V, BRD3 Inhibitor IV, BRD4 Inhibitor V
References
ReferencesDittman, et al. 2014. ACS Chem Biol. 9, 495.
Ding, J., et al. 1995. J. Biol. Chem. 270, 11684.
Vlahos, C.J., et al. 1994. J. Biol. Chem. 269, 5241.
Product Information
CAS number154447-38-8
ATP CompetitiveN
FormAmber solid
Hill FormulaC₁₉H₁₈N₂O₂
Chemical formulaC₁₉H₁₈N₂O₂
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetNegative control for the PI 3-kinase inhibitor LY 294002
Primary Target IC<sub>50</sub>Does not inhibit PI 3-kinase even at a concentration of 100 µM
Purity≥98% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
440203 0

Documentation

LY 303511 - CAS 154447-38-8 - Calbiochem MSDS

Title

Safety Data Sheet (SDS) 

LY 303511 - CAS 154447-38-8 - Calbiochem Certificates of Analysis

TitleLot Number
440203

References

Reference overview
Dittman, et al. 2014. ACS Chem Biol. 9, 495.
Ding, J., et al. 1995. J. Biol. Chem. 270, 11684.
Vlahos, C.J., et al. 1994. J. Biol. Chem. 269, 5241.

Posters

Title
Human Kinome & InhibitorSelect™ Libraries
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision13-September-2007 JSW
Synonyms2-Piperazinyl-8-phenyl-4H-1-benzopyran-4-one, BRD2 Inhibitor V, BRD3 Inhibitor IV, BRD4 Inhibitor V
DescriptionA cell-permeable, negative control for the phosphatidylinositol-3-kinase (PI-3 kinase) inhibitor, LY 294002 (Cat. No. 440202). Contains a single atom substitution in the morpholine ring compared to LY 294002. Does not affect PI-3 kinase activity even at concentrations ≥100 µM.
FormAmber solid
CAS number154447-38-8
Chemical formulaC₁₉H₁₈N₂O₂
Structure formulaStructure formula
Purity≥98% by HPLC
SolubilityDMSO (100 mg/ml)
Storage -20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
Toxicity Standard Handling
ReferencesDittman, et al. 2014. ACS Chem Biol. 9, 495.
Ding, J., et al. 1995. J. Biol. Chem. 270, 11684.
Vlahos, C.J., et al. 1994. J. Biol. Chem. 269, 5241.