Millipore Sigma Vibrant Logo
Attention: We have moved. Merck Millipore products are no longer available for purchase on MerckMillipore.com.Learn More

509703 LSD1 Inhibitor VII, SP-2509 - CAS 1423715-09-6 - Calbiochem

A cell-permeable, potent, selective, reversible inhibitor of Lysine-Specific Demethylase 1 (LSD1; IC₅₀ = 13 nM; Ki = 31 nM).

LSD1 Inhibitor VII, SP-2509 - CAS 1423715-09-6 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: BHC110 Inhibitor VII, Histone Lysine Demethylase Inhibitor XIV, KIAA1718 Inhibitor VII, LSD Inhibitor VII, SP-2509

Primary Target: LSD1
509703
Purchase on Sigma-Aldrich

Overview

Key Spec Table

CAS #Empirical Formula
1423715-09-6C₁₉H₂₀ClN₃O₅S

Products

Catalogue NumberPackaging Qty/Pack
5.09703.0001 Sklená flaša 10 mg
Add To Favorites
Description
OverviewA cell-permeable phenethylidene-benzohydrazide compound that acts as a potent, selective, reversible, and non-competitive inhibitor of Lysine-Specific Demethylase 1 (LSD1; IC50 = 13 nM; Ki = 31 nM). Exhibits excellent selectivity over monoamine oxidases A and B (IC50 > 300 µM), lactate dehydrogenase, glucose oxidase, hERG, CYP1A2, CYP2D6 (IC50 ≥ 10 µM), CYP2C9 (IC50 = 8.04 µM) and CYP2C19 (IC50 = 9.76 µM). Inhibits CYP3A4 only at >200-fold higher concentration. Reduces the proliferation of several cancer cell lines, including AN3 Ca, BT-20, MCF-7, T-47D, HT29, MIA PaCa-2 and SK-N-MC (IC50 = 356, 489, 637, 649, 429, 468 and 329 nM, respectively).
Catalogue Number509703
Brand Family Calbiochem®
SynonymsBHC110 Inhibitor VII, Histone Lysine Demethylase Inhibitor XIV, KIAA1718 Inhibitor VII, LSD Inhibitor VII, SP-2509
References
ReferencesFiskus, W., et al. 2014. Leukemia 28, 2155.
Sorna, V., et al. 2013. J. Med. Chem. 56, 9496.
Product Information
CAS number1423715-09-6
FormOff-white solid
Hill FormulaC₁₉H₂₀ClN₃O₅S
Chemical formulaC₁₉H₂₀ClN₃O₅S
ReversibleY
Structure formula ImageStructure formula Image
Quality LevelMQ100
Biological Information
Primary TargetLSD1
Purity≥98% by HPLC
Physicochemical Information
Cell permeableY
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Global Trade Item Number
Catalogue Number GTIN
5.09703.0001 04055977241037