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108396 L-Tryptofán

EMPROVE® EXPERT Ph Eur,BP,JP,USP

L-Tryptofán MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Trp

CAS #: 73-22-3 EC Number: 200-795-6 Molar Mass: 204.23 g/mol Hill Formula: C₁₁H₁₂N₂O₂ Grade: Ph Eur,BP,JP,USP
108396
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Overview

Key Spec Table

CAS #EC NumberHill FormulaMolar MassGrade Value
73-22-3200-795-6C₁₁H₁₂N₂O₂204.23 g/molPh Eur,BP,JP,USP

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Catalogue NumberPackaging Qty/Pack
1083961000 Plastová flaša 1 kg
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1083969010 Plastový sud 10 kg
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Description
Catalogue Number108396
SynonymsTrp
Product Information
CAS number73-22-3
EC number200-795-6
GradePh Eur,BP,JP,USP
Hill FormulaC₁₁H₁₂N₂O₂
Molar Mass204.23 g/mol
HS Code2933 99 99
Structure formula ImageStructure formula Image
Quality LevelMQ500
Physicochemical Information
Melting Point290 °C (rozklad)
pH value5.5 - 7 (1 g/l, H₂O, 25 °C)
Bulk density400 kg/m3
Solubility10 g/l
Toxicological Information
LD 50 oralLD50 Potkan 16000 mg/kg
Safety Information according to GHS
RTECSYN6130000
Storage class10 - 13 Iné kvapaliny a tuhé látky
WGKWGK 1 mierne ohrozujúce vody
Disposal3
Relatívne nereaktívne organické reagencie je potrebné zhromaždovať v nádobe A. Ak sú halogénované, je potrebné ich zhromaždovať v nádobe B. Pre tuhé zvyšky použite nádobu C.
Storage and Shipping Information
StorageSkladujte pri +2°C až +30°C.
Specifications
Assay (perchloric acid titration, calculated on dried substance)98.5 - 101.0 %
Identity (IR-spectrum)passes test
Identity (specific rotation)passes test
Appearancewhite to almost white, crystalline or amorphous powder
Appearance of solution (10 g/l, Hydrochloric acid 1 mol/l)clear and not more intense in color than reference solution BY₆
Appearance of solution (20 g/l, hydrochloric acid 2 mol/l)clear
pH (10 g/l, CO₂-free water)5.5 - 6.4
Spec. rotation (α 20/D, 10 g/l, water, calc. on dried substance)-30.0 to -33.0
Spec. rotation (α 25/D, 10 g/l, water, calc. on dried substance)-29.4 to -32.8
Spec. rotation (α 20/D, 10 g/l, water, previously dried substance)-30.0 to -33.0
Chloride (Cl)≤ 200 ppm
Sulfate (SO₄)≤ 200 ppm
Heavy metals (as Pb)≤ 20 ppm
Fe (Iron)≤ 20 ppm
As (Arsenic)≤ 2 ppm
Ninhydrin-positive substances (LC) (any ninhydrin-positive impurity)≤ 0.2 %
Ninhydrin-positive substances (LC) (ammonium (570 nm))≤ 0.02 %
Ninhydrin-positive substances (LC) (total impurities)≤ 0.5 %
Related substances (HPLC)passes test
Impurity A ((1,1‘-ethylidenebistryptophan) Peak-E) (acc. to Ph Eur)≤ 10 ppm
Sum of impurities with RT < tryptophan-peak (acc. to Ph Eur)≤ 100 ppm
Sum of impurities with RT > tryptophan-peak and up to1,8 times the RT ofacetyltryptophan (acc. to Ph Eur)≤ 300 ppm
Impurity A ((1,1‘-ethylidenebistryptophan) Peak-E) (acc. to USP)≤ 10 ppm
Sum of impurities with RT < tryptophan-peak (acc. to USP)≤ 100 ppm
Sum of impurities with RT > tryptophan-peak, without tryptophan-peak andpeak of „Related Compound B“ (N-acetyltryptophan) (acc. to USP)≤ 300 ppm
Related substances (TLC)passes test
Residual solvents (ICH (Q3C))excluded by manufacturing process
Sulfated ash (600 °C)≤ 0.1 %
Loss on drying (105 °C; 3 h)≤ 0.30 %
Bacterial endotoxins≤ 10 I.U./g
Microbiological test (total aerobic microbial count (TAMC))≤ 100 CFU/g
Microbiological test (total yeast and mould count (TYMC))≤ 100 CFU/g
Elemental impurity specifications have been set considering ICH Q3D (Guideline for Elemental Impurities). Class 1-3 elements are not likely to be present above the ICH Q3D option 1 limit, unless specified and indicated (*).
Corresponds to Ph. Eur., BP, JP, USP.
Global Trade Item Number
Catalogue Number GTIN
1083961000 04022536104003
1083969010 04022536732701