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420600 Ketoconazole - CAS 65277-42-1 - Calbiochem

An inhibitor of cytochrome P-450 in steroid biosynthesis. An antifungal agent that displays potent anti-metastatic, anti-neoplastic, and anti-psoriatic activities.

Ketoconazole - CAS 65277-42-1 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: cis-1-Acetyl-4-[4-[[2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazine, R-41400, CYP17A1 Inhibitor I

Primary Target: 5-LO
420600
Purchase on Sigma-Aldrich

Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
65277-42-1C₂₆H₂₈Cl₂N₄O₄

Products

Catalogue NumberPackaging Qty/Pack
420600-50MG Sklená flaša 50 mg
Description
OverviewAn inhibitor of cytochrome P-450 in steroid biosynthesis. An antifungal agent that displays potent anti-metastatic, anti-neoplastic, and anti-psoriatic activities. Also acts as an inhibitor of 5-lipoxygenase (5-LO; IC50 = 26 µM) and thromboxane synthase activities.
Catalogue Number420600
Brand Family Calbiochem®
Synonymscis-1-Acetyl-4-[4-[[2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazine, R-41400, CYP17A1 Inhibitor I
References
Referencesvan Wauwe, J.P., and Janssen, P.A.J. 1989. J. Med. Chem. 32, 2231.
Beetens, J.R., et al. 1986. Biochem. Pharmacol. 35, 883.
Lambert, A., et al. 1986. Biochem. Pharmacol. 35, 3999.
Tucker, W.F.G., and MacNeil, S. 1986. Br. Med. J. 293, 882.
Lelcuk, S., et al. 1984. J. Trauma 24, 393.
Product Information
CAS number65277-42-1
FormOff-white solid
Hill FormulaC₂₆H₂₈Cl₂N₄O₄
Chemical formulaC₂₆H₂₈Cl₂N₄O₄
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary Target5-LO
Primary Target IC<sub>50</sub>26 µM
Purity≥98% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
RTECSTK7912300
Safety Information
R PhraseR: 25-40-63-36/37/38

Toxic if swallowed.
Limited evidence of a carcinogenic effect.
Possible risk of harm to the unborn child.
Irritating to eyes, respiratory system and skin.
S PhraseS: 22-26-36

Do not breathe dust.
In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
Wear suitable protective clothing.
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Toxic & Carcinogenic / Teratogenic
Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Storage +2°C to +8°C
Do not freeze Ok to freeze
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
420600-50MG 04055977187618

Documentation

Ketoconazole - CAS 65277-42-1 - Calbiochem MSDS

Title

Safety Data Sheet (SDS) 

Ketoconazole - CAS 65277-42-1 - Calbiochem Certificates of Analysis

TitleLot Number
420600

References

Reference overview
van Wauwe, J.P., and Janssen, P.A.J. 1989. J. Med. Chem. 32, 2231.
Beetens, J.R., et al. 1986. Biochem. Pharmacol. 35, 883.
Lambert, A., et al. 1986. Biochem. Pharmacol. 35, 3999.
Tucker, W.F.G., and MacNeil, S. 1986. Br. Med. J. 293, 882.
Lelcuk, S., et al. 1984. J. Trauma 24, 393.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision13-May-2008 RFH
Synonymscis-1-Acetyl-4-[4-[[2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazine, R-41400, CYP17A1 Inhibitor I
DescriptionAn inhibitor of cytochrome P-450 in steroid biosynthesis. An anti-fungal agent that displays potent anti-metastatic, anti-neoplastic, and anti-psoriatic activities. Also acts as an inhibitor of 5-lipoxygenase (5-LO; IC50 = 26 µM) and thromboxane synthase activities.
FormOff-white solid
CAS number65277-42-1
RTECSTK7912300
Chemical formulaC₂₆H₂₈Cl₂N₄O₄
Structure formulaStructure formula
Purity≥98% by HPLC
Storage +2°C to +8°C
Do Not Freeze Ok to freeze
Toxicity Toxic & Carcinogenic / Teratogenic
Merck USA index14, 5302
Referencesvan Wauwe, J.P., and Janssen, P.A.J. 1989. J. Med. Chem. 32, 2231.
Beetens, J.R., et al. 1986. Biochem. Pharmacol. 35, 883.
Lambert, A., et al. 1986. Biochem. Pharmacol. 35, 3999.
Tucker, W.F.G., and MacNeil, S. 1986. Br. Med. J. 293, 882.
Lelcuk, S., et al. 1984. J. Trauma 24, 393.