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530537 JmjC Histone Demethylase Inhibitor, n-Octyl-IOX1 - CAS 1586038-75-6 - Calbiochem

A cell-permeable, superior inhibitor of Jumonji C domain histone lysine demethylase. About 30 fold more potent than IOX1 (EC₅₀ = 3.8 µM for KDM4A in HeLa cells vs. 100 µM for IOX1).

JmjC Histone Demethylase Inhibitor, n-Octyl-IOX1 - CAS 1586038-75-6 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: KDM4 Inhibitor

Primary Target: KDM4
530537
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
1586038-75-6C₁₈H₂₃NO₃

Products

Catalogue NumberPackaging Qty/Pack
5.30537.0001 Sklená flaša 10 mg
Description
OverviewA cell-permeable, non-toxic, n-octyl ester form of 5-carboxy-8-hydroxyquinoline (IOX1, Cat. No. 420201) that acts as a superior inhibitor of Jumonji C domain histone lysine demethylase. Shown to be about 30 fold more potent than IOX1 (EC50 = 3.8 µM for KDM4A in HeLa cells vs. 100 µM for IOX1). Inhibits the H3K9 me3 demethylation activity of KDM4C (IC50 = 3.9 µM in ALPHA Screen assay). Exhibits greater stability to hydrolysis in the ALPHA Screen buffer.

Please note that the molecular weight for this compound is batch-specific due to variable water content.
Catalogue Number530537
Brand Family Calbiochem®
SynonymsKDM4 Inhibitor
References
ReferencesSchiller, R., et al. 2014. ChemMedChem. 9,566.
Product Information
CAS number1586038-75-6
FormGrey-green solid
Hill FormulaC₁₈H₂₃NO₃
Chemical formulaC₁₈H₂₃NO₃
ReversibleY
Quality LevelMQ100
Applications
Biological Information
Primary TargetKDM4
Purity≥98% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
5.30537.0001 04055977260885

Documentation

JmjC Histone Demethylase Inhibitor, n-Octyl-IOX1 - CAS 1586038-75-6 - Calbiochem MSDS

Title

Safety Data Sheet (SDS) 

References

Reference overview
Schiller, R., et al. 2014. ChemMedChem. 9,566.

Technical Info

Title
White Paper - The Message in the Marks: Deciphering Cancer Epigenetics
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision20-June-2014 JSW
SynonymsKDM4 Inhibitor
DescriptionA cell-permeable, non-toxic, n-octyl ester form of 5-carboxy-8-hydroxyquinoline (IOX1, Cat. No. 420201) that acts as a superior inhibitor of Jumonji C domain histone lysine demethylase. Shown to be about 30 fold more potent than IOX1 (EC50 = 3.8 µM for KDM4A in HeLa cells vs. 100 µM for IOX1). Inhibits the H3K9 me3 demethylation activity of KDM4C (IC50 = 3.9 µM in ALPHA Screen assay). Exhibits greater stability to hydrolysis in the ALPHA Screen buffer.
FormGrey-green solid
Intert gas (Yes/No) Packaged under inert gas
CAS number1586038-75-6
Chemical formulaC₁₈H₂₃NO₃
Purity≥98% by HPLC
SolubilityDMSO (5 mg/ml)
Storage Protect from light
-20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesSchiller, R., et al. 2014. ChemMedChem. 9,566.