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412520 Iron Chelator, Dp44mT - CAS 152095-12-0 - Calbiochem

Prevents the aggressive growth of M109 lung carcinoma in mice without affecting body weight. Shown to mobilize cellular iron effectively, and generate ROS leading to apoptosis.

Iron Chelator, Dp44mT - CAS 152095-12-0 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 2,2ʹ-Dipyridyl-N,N-dimethylsemicarbazone

412520
  
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Overview

Replacement Information
Description
Overview

This product has been discontinued.





A cell-permeable di-2-pyridyl thiosemicarbazone (DpT) based tridentate ligand that displays potent and selective antiproliferative properties in neoplastic cells (IC50 ≤ 0.06 µM in SK-N-MC, SK-Mel-28 and MCF-7 cells) and minimally affects normal cells (IC50 > 25 µM in MRC-5). Prevents the aggressive growth of M109 lung carcinoma in mice without affecting body weight. Shown to mobilize cellular iron effectively, and generate ROS leading to apoptosis.
Catalogue Number412520
Brand Family Calbiochem®
Synonyms2,2ʹ-Dipyridyl-N,N-dimethylsemicarbazone
References
ReferencesYuan, J., et al. 2004. Blood 104, 1450.
Product Information
CAS number152095-12-0
FormYellow solid
Hill FormulaC₁₄H₁₅N₅S
Chemical formulaC₁₄H₁₅N₅S
Structure formula ImageStructure formula Image
Applications
Biological Information
Purity≥95% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity Carcinogenic / Teratogenic
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
412520 0

Documentation

Iron Chelator, Dp44mT - CAS 152095-12-0 - Calbiochem MSDS

Title

Safety Data Sheet (SDS) 

Iron Chelator, Dp44mT - CAS 152095-12-0 - Calbiochem Certificates of Analysis

TitleLot Number
412520

References

Reference overview
Yuan, J., et al. 2004. Blood 104, 1450.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision13-April-2011 RFH
Synonyms2,2ʹ-Dipyridyl-N,N-dimethylsemicarbazone
DescriptionA cell-permeable di-2-pyridyl thiosemicarbazone (DpT) based tridentate ligand that exhibits potent and selective anti-proliferative properties in neoplastic cells (IC50 ≤60 nM in SK-N-MC, SK-Mel-28 and MCF-7 cells) with minimal effects on normal cells (IC50 >25 µM in MRC-5). Prevents the aggressive growth of M109 lung carcinoma in mice without affecting their body weight. Its autitumor effects are believed to be linked to activation of caspase-3. Shown to mobilize cellular iron effectively, generating ROS that leads to apoptosis.
FormYellow solid
Intert gas (Yes/No) Packaged under inert gas
CAS number152095-12-0
Chemical formulaC₁₄H₁₅N₅S
Structure formulaStructure formula
Purity≥95% by HPLC
SolubilityDMSO (5 mg/ml)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity Carcinogenic / Teratogenic
ReferencesYuan, J., et al. 2004. Blood 104, 1450.