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IL017 Interleukin-6 Protein, Recombinant mouse

The recombinant mouse Interleukin-6 protein (or IL-6 protein) is a potent lymphoid cell growth factor which affects B-lymphocytes, T-lymphocytes & hybridoma cells.

Interleukin-6 Protein, Recombinant mouse MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Key Applications: Cell Culture UniProt Number: P05231, P08505
IL017
10 µg  
Purchase on Sigma-Aldrich

Overview

Replacement Information

Key Spec Table

Key ApplicationsSpeciesPurity
CULTMouse Greater than 98% by SDS-PAGE and HPLC analysis. Endotoxin level is less than 0.1 ng per μg (1EU/μg) of mouse IL-6.
Description
Catalogue NumberIL017
Brand Family Chemicon®
Trade Name
  • Chemicon
DescriptionInterleukin-6 Protein, Recombinant mouse
OverviewInterleukin-6 (IL-6) is a potent lymphoid cell growth factor which stimulates the growth and survivability of certain B-cells and T-cells. Mouse IL-6 is a 21.7 kDa protein containing 187 amino acid residues.
Alternate Names
  • IL-6
References
Product Information
PresentationSterile filtered, and then lyophilized with no additives.
Quality LevelMQ100
Applications
ApplicationThe recombinant mouse Interleukin-6 protein (or IL-6 protein) is a potent lymphoid cell growth factor which affects B-lymphocytes, T-lymphocytes & hybridoma cells.
Key Applications
  • Cell Culture
Application NotesFor most in vitro applications, mouse IL-6 exerts its biological activity in the concentration range of 0.1 to 10.0 ng/mL. Responding cells are (partial list): B-cells, hybridoma cells.
Biological Information
PurityGreater than 98% by SDS-PAGE and HPLC analysis. Endotoxin level is less than 0.1 ng per μg (1EU/μg) of mouse IL-6.
Specific ActivityThe ED(50) was determined by the dose-dependent stimulation of the proliferation of IL-6 dependent mouse 7TD1 cells is <= 0.02 ng/mL, corresponding to a specific activity of >=5 x 10(E8) units/mg.
UniProt Number
UniProt SummaryFUNCTION: SwissProt: P05231 # IL-6 is a cytokine with a wide variety of biological functions: it plays an essential role in the final differentiation of B-cells into Ig-secreting cells, it induces myeloma and plasmacytoma growth, it induces nerve cells differentiation, in hepatocytes it induces acute phase reactants.
SIZE: 212 amino acids; 23718 Da
SUBCELLULAR LOCATION: Secreted.
PTM: N- and O-glycosylated.
DISEASE: SwissProt: P05231 # Genetic variations in IL6 are associated with susceptibility to systemic juvenile rheumatoid arthritis [MIM:604302]. Systemic juvenile rheumatoid arthritis is juvenile chronic arthritis associated with severe, debilitating, extraarticular features, and occasionally fatal complications. Despite medical treatment, many children still experience early joint destruction, necessitating surgical replacement. & At least 1 polymorphism in the IL6 gene renders HIV- infected men susceptible to Kaposi sarcoma [MIM:148000]. Kaposi sarcoma is a sarcoma of spindle cells mixed with angiomatous tissue. A relatively rare malignant skin tumor that results in multifocal purplish coloured papules or plaques that eventually form nodules. Most commonly seen in patients who suffer from AIDS.
SIMILARITY: SwissProt: P05231 ## Belongs to the IL-6 superfamily.
Stem Cell Type
  • Hematopoietic Stem Cells
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsThe lyophilized powder is stable for a few weeks at room temperature, but best stored at -20ºC for up to 12 months after date of receipt. After a quick spin, reconstitute with sterile water to a concentration of 0.1-1.0 mg/mL. This solution can then be diluted into other aqueous buffers and stored at 2-8°C for one week or -20°C for future use. Reconstituted mouse IL-6 should be stored in undiluted aliquots at -20°C for up to 6 months.
Packaging Information
Material Size10 µg
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
IL017 04053252275432

Documentation

Interleukin-6 Protein, Recombinant mouse MSDS

Title

Safety Data Sheet (SDS) 

Interleukin-6 Protein, Recombinant mouse Certificates of Analysis

TitleLot Number
/RECOMBINANT MOUSE INTERLEUKIN-6_2843087 2843087
RECOMBINANT MOUSE INTERLEUKIN-6 2919161
RECOMBINANT MOUSE INTERLEUKIN-6 3036934
RECOMBINANT MOUSE INTERLEUKIN-6 2945832
RECOMBINANT MOUSE INTERLEUKIN-6 2462766
RECOMBINANT MOUSE INTERLEUKIN-6 - 2332497 2332497
RECOMBINANT MOUSE INTERLEUKIN-6 - 2061626 2061626
RECOMBINANT MOUSE INTERLEUKIN-6 - 2064688 2064688
RECOMBINANT MOUSE INTERLEUKIN-6 - 2091674 2091674
RECOMBINANT MOUSE INTERLEUKIN-6 - 2159627 2159627
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Data Sheet

Title
RECOMBINANT MOUSE INTERLEUKIN-6

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