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407245 Insulin-Like Growth Factor-II, Human, Recombinant, E. coli

Insulin-Like Growth Factor-II, Human, Recombinant, E. coli MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: rhIGF-II

407245
  
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Overview

Replacement Information

Key Spec Table

Purity
≥97% by SDS-PAGE
Description
OverviewRecombinant, human insulin-like growth factor-II expressed in E. coli. Its actions are similar to IGF-1 (Cat. No. 407240). Plays an important role in fetal development. Stimulates muscle and bone cell proliferation and differentiation.
Catalogue Number407245
Brand Family Calbiochem®
SynonymsrhIGF-II
References
ReferencesFeldser, D., et al. 1999. Cancer Res. 59, 3915.
Hill, P.A., et al. 1995. Endocrinology 136, 124.
Nielson, F.C., et al. 1995. Nature 377, 358.
LeRoith, D., and Roberts, C.R., Jr. 1993. Ann. N.Y. Acad. Sci. 692, 1.
Lowe, W.L. 1991. In Insulin-Like Growth Factors: Molecular and Cellular Aspects (LeRoith, D., Ed.) CRC Press Inc., Boca Raton p. 49.
Rotwein, P. 1991. Growth Factors 5, 3.
Product Information
CAS number67763-97-7
FormLyophilized
FormulationLyophilized from sterile-filtered acetic acid.
Quality LevelMQ100
Applications
Biological Information
Biological activityED₅₀ = 5-10 ng/ml
Purity≥97% by SDS-PAGE
Physicochemical Information
ContaminantsEndotoxin: <1 EU/µg IGF-II
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
RTECSNM8906000
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-70°C). Stock solutions are stable for up to 3 months at -70°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
407245 0

Documentation

Insulin-Like Growth Factor-II, Human, Recombinant, E. coli MSDS

Title

Safety Data Sheet (SDS) 

Insulin-Like Growth Factor-II, Human, Recombinant, E. coli Certificates of Analysis

TitleLot Number
407245

References

Reference overview
Feldser, D., et al. 1999. Cancer Res. 59, 3915.
Hill, P.A., et al. 1995. Endocrinology 136, 124.
Nielson, F.C., et al. 1995. Nature 377, 358.
LeRoith, D., and Roberts, C.R., Jr. 1993. Ann. N.Y. Acad. Sci. 692, 1.
Lowe, W.L. 1991. In Insulin-Like Growth Factors: Molecular and Cellular Aspects (LeRoith, D., Ed.) CRC Press Inc., Boca Raton p. 49.
Rotwein, P. 1991. Growth Factors 5, 3.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision13-May-2008 RFH
SynonymsrhIGF-II
DescriptionRecombinant, human insulin-like growth factor-II expressed in E. coli. A growth-promoting peptide that is structurally related to insulin. IGF-II shares about 76% sequence identity with IGF-I and ~50% with pro-insulin. Its actions are similar to IGF-I (Cat. No. 407240). IGF-II is a nonglycosylated, single chain peptide of 67 amino acids. Plays an important role in fetal development. Stimulates muscle and bone cell proliferation and differentiation.
FormLyophilized
FormulationLyophilized from sterile-filtered acetic acid.
CAS number67763-97-7
RTECSNM8906000
Purity≥97% by SDS-PAGE
ContaminantsEndotoxin: <1 EU/µg IGF-II
Biological activityED₅₀ = 5-10 ng/ml
SolubilityReconstitute to a concentration of ≥10 µg/ml with sterile PBS containing ≥0.1% HSA or BSA. Avoid using buffers near the isoelectric point (6.5).
Storage -20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-70°C). Stock solutions are stable for up to 3 months at -70°C.
Toxicity Standard Handling
Merck USA index14, 4986
ReferencesFeldser, D., et al. 1999. Cancer Res. 59, 3915.
Hill, P.A., et al. 1995. Endocrinology 136, 124.
Nielson, F.C., et al. 1995. Nature 377, 358.
LeRoith, D., and Roberts, C.R., Jr. 1993. Ann. N.Y. Acad. Sci. 692, 1.
Lowe, W.L. 1991. In Insulin-Like Growth Factors: Molecular and Cellular Aspects (LeRoith, D., Ed.) CRC Press Inc., Boca Raton p. 49.
Rotwein, P. 1991. Growth Factors 5, 3.