324897 Sigma-AldrichInSolution™ eIF-2α Inhibitor, Salubrinal - CAS 304475-63-6 - Calbiochem
The InSolution™ eIF-2α Inhibitor, Salubrinal, also referenced under CAS 304475-63-6, controls the biological activity of eIF-2α. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
More>> The InSolution™ eIF-2α Inhibitor, Salubrinal, also referenced under CAS 304475-63-6, controls the biological activity of eIF-2α. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications. Less<<InSolution™ eIF-2α Inhibitor, Salubrinal - CAS 304475-63-6 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Synonyms: N-(2,2,2-Tichloro-1-(3-quinolin-8-ylthioureido)ethyl)cinnamamide
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Overview
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Key Spec Table
| CAS # | Empirical Formula |
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| 304475-63-6 | C₂₁H₁₇Cl₃N₄OS |
| Description | |
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| Overview | A cell-permeable and selective inhibitor of the phosphatase complexes that dephosphorylate eukaryotic translation initiation factor 2 subunit α (eIF-2α). Shown to offer protection against ER stress-induced apoptosis (EC50 ~15 µM in PC12 cells stimulated with 750 ng/ml of Tunicamycin (Cat. No. 654380). Prevents HSV replication both in Vero cells (IC50 ~3 µM for reducing plaque formation) in vitro and in a mouse cornea infection model in vivo. The solid form of this compound (Cat. No. 324895) is also available. |
| Catalogue Number | 324897 |
| Brand Family | Calbiochem® |
| Synonyms | N-(2,2,2-Tichloro-1-(3-quinolin-8-ylthioureido)ethyl)cinnamamide |
| References | |
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| References | Boyce, M., et al. 2005. Science 307, 935. |
| Product Information | |
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| CAS number | 304475-63-6 |
| Form | Liquid |
| Formulation | A 50 mM (5 mg/208 µL) solution of eIF-2α Inhibitor, Salubrinal (Cat. No. 324895) in DMSO. |
| Hill Formula | C₂₁H₁₇Cl₃N₄OS |
| Hygroscopic | Hygroscopic |
| Structure formula Image | |
| Quality Level | MQ100 |
| Applications |
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| Biological Information | |
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| Primary Target | eIF-2α |
| Purity | ≥95% by HPLC |
| Physicochemical Information | |
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| Cell permeable | Y |
| Dimensions |
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| Materials Information |
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| Toxicological Information |
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| Safety Information according to GHS |
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| Product Usage Statements |
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| Packaging Information | |
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| Packaged under inert gas | Packaged under inert gas |
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| Specifications |
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| Global Trade Item Number | |
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| Catalogue Number | GTIN |
| 324897 | 0 |
Documentation
InSolution™ eIF-2α Inhibitor, Salubrinal - CAS 304475-63-6 - Calbiochem MSDS
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InSolution™ eIF-2α Inhibitor, Salubrinal - CAS 304475-63-6 - Calbiochem Certificates of Analysis
| Title | Lot Number |
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| 324897 |
References
| Reference overview |
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| Boyce, M., et al. 2005. Science 307, 935. |
| Data Sheet | ||||||||||||||||||||||||||||
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Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
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