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551476 InSolution™ Q-VD-OPh, Non-O-methylated - Calbiochem

InSolution™ Q-VD-OPh, Non-O-methylated, is a cell-permeable, irreversible, broad-spectrum inhibitor of caspases (IC₅₀ = 50, 100, 430, and <25 nM for caspase-1,-8, -9, and -3, respectively).

InSolution™ Q-VD-OPh, Non-O-methylated - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: N-(2-Quinolyl)valyl-aspartyl-(2,6-difluorophenoxy)methyl Ketone

Primary Target: caspase-1
551476
Purchase on Sigma-Aldrich

Overview

Replacement Information

Key Spec Table

Empirical Formula
C₂₆H₂₅F₂N₃O₆

Products

Catalogue NumberPackaging Qty/Pack
551476-1MG Plastová ampulka 1 mg
551476-5MG Sklená flaša 5 mg
Description
OverviewA cell-permeable, irreversible, broad-spectrum caspase inhibitor (IC50 = 50, 100, 430, and <25 nM for caspase-1,-8, -9, and -3, respectively) with effective antiapoptotic properties against all major caspase-mediated cellular apoptosis pathways. Exhibits no cytotoxic effects even at extremely high concentrations. Shown to reduce ischemic brain damage and stroke-induced programmed cell death in thymus and spleen.
Catalogue Number551476
Brand Family Calbiochem®
SynonymsN-(2-Quinolyl)valyl-aspartyl-(2,6-difluorophenoxy)methyl Ketone
References
ReferencesBraun, J.S., et al. 2007. Exp. Neurol. 206, 183.
Caserta, T.M., et al. 2003. Apoptosis 8, 345.
Rebbaa, A., et al. 2003. Oncogene 22, 2805.
Product Information
ATP CompetitiveN
FormLiquid
FormulationSupplied as a 10 mM (1 mg/195 µl) solution in DMSO.
Hill FormulaC₂₆H₂₅F₂N₃O₆
Chemical formulaC₂₆H₂₅F₂N₃O₆
Hygroscopic Hygroscopic
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary Targetcaspase-1
Primary Target IC<sub>50</sub>50, 100, 430, and <25 nM for caspase-1,-8, -9, and -3, respectively
Purity≥90% by HPLC
Physicochemical Information
Cell permeableY
Peptide SequenceQ-Val-Asp-CH₂-OPh
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped with Blue Ice or with Dry Ice
Toxicity Irritant
Storage -20°C
Protect from Light Protect from light
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
551476-1MG 04055977268898
551476-5MG 04055977268904

Documentation

InSolution™ Q-VD-OPh, Non-O-methylated - Calbiochem MSDS

Title

Safety Data Sheet (SDS) 

InSolution™ Q-VD-OPh, Non-O-methylated - Calbiochem Certificates of Analysis

TitleLot Number
551476

References

Reference overview
Braun, J.S., et al. 2007. Exp. Neurol. 206, 183.
Caserta, T.M., et al. 2003. Apoptosis 8, 345.
Rebbaa, A., et al. 2003. Oncogene 22, 2805.

Brochure

Title
Caspases and other Apoptosis Related Tools Brochure

Citations

Title
  • Braun, J.S., et al. 2007. Exp. Neurol. 206, 183.
  • Jessica H. Dworet and Judy L. Meinkoth. 2006.Molecular Endocrinology 20, 1112.
  • Ademi E. Santiago-Walker, et al. (2005) Protein Kinase C δ Stimulates Apoptosis by Initiating G1 Phase Cell Cycle Progression and S Phase Arrest. Journal of Biological Chemistry 280, 32107-32114.
    		•
    Data Sheet

    Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

    Revision28-February-2012 RFH
    SynonymsN-(2-Quinolyl)valyl-aspartyl-(2,6-difluorophenoxy)methyl Ketone
    DescriptionA cell-permeable, irreversible, broad-spectrum caspase inhibitor (IC50 = 50 nM for caspase-1; IC50 = 100 nM for caspase-8; IC50 = 430 nM for caspase-9; IC50 < 25 nM for caspase-3). Exhibits effective anti-apoptotic properties against all major caspase-mediated cellular apoptosis pathways, including caspase 9/3, caspase 8/10, and caspase 12. Does not exhibit toxic effects even at high concentrations. To reduce hydrophobicity of the peptide and facilitate its use in aqueous media the aspartyl residue is not O-methylated. Shown to reduce ischemic brain damage and stroke-induced programmed cell death in thymus and spleen.
    FormLiquid
    FormulationSupplied as a 10 mM (1 mg/195 µl) solution in DMSO.
    Intert gas (Yes/No) Packaged under inert gas
    Chemical formulaC₂₆H₂₅F₂N₃O₆
    Peptide SequenceQ-Val-Asp-CH₂-OPh
    Structure formulaStructure formula
    Purity≥90% by HPLC
    Storage Protect from light
    -20°C
    Hygroscopic
    Do Not Freeze Ok to freeze
    Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
    Toxicity Irritant
    ReferencesBraun, J.S., et al. 2007. Exp. Neurol. 206, 183.
    Caserta, T.M., et al. 2003. Apoptosis 8, 345.
    Rebbaa, A., et al. 2003. Oncogene 22, 2805.
    Citation
  • Braun, J.S., et al. 2007. Exp. Neurol. 206, 183.
  • Jessica H. Dworet and Judy L. Meinkoth. 2006.Molecular Endocrinology 20, 1112.
  • Ademi E. Santiago-Walker, et al. (2005) Protein Kinase C δ Stimulates Apoptosis by Initiating G1 Phase Cell Cycle Progression and S Phase Arrest. Journal of Biological Chemistry 280, 32107-32114.
    		•