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496000 InSolution™ OM99-2 - CAS 314266-76-7 - Calbiochem

An eight residue peptidomimetic, tight binding transition-state analog inhibitor of human brain memapsin 2.

InSolution™ OM99-2 - CAS 314266-76-7 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: EVNLΨAAEF

Primary Target: human brain memapsin 2
496000
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
314266-76-7C₄₁H₆₄N₈O₁₄

Products

Catalogue NumberPackaging Qty/Pack
496000-250UG Plastová ampulka 250 μg
Description
OverviewAn eight residue peptidomimetic, tight binding transition-state analog inhibitor of human brain memapsin 2 (Ki = 1.6 nM, recombinant memapsin 2; Ki = 9.58 nM, recombinant pro-memapsin 2). Also inhibits cathepsin D (Ki = 48 nM). This aspartyl protease inhibitor is designed from the template of the β-secretase site of Swedish β-amyloid precursor protein (APP) with Asp to Ala replacement; also includes a nonhydrolyzable hydroxyethylene isostere between Leu and Ala.
Catalogue Number496000
Brand Family Calbiochem®
SynonymsEVNLΨAAEF
References
ReferencesGhosh, A.K., et al. 2001. J. Med. Chem. 44, 2865.
Turner III, R.T., et al. 2001. Biochemistry 40, 10001.
Ghosh, A.K., et al. 2000. J. Am. Chem. Soc. 122, 3522.
Hong, L., et al. 2000. Science 290,150.
Product Information
CAS number314266-76-7
ATP CompetitiveN
FormLiquid
FormulationA 1 mM (250µg in 280 µl) solution in DMSO. Supplied as a trifluoroacetate salt.
Hill FormulaC₄₁H₆₄N₈O₁₄
Chemical formulaC₄₁H₆₄N₈O₁₄
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary Targethuman brain memapsin 2
Primary Target K<sub>i</sub>1.6 nM against recombinant memapsin 2; 9.58 nM against recombinant pro-memapsin 2; 48 nM against cathepsin D
Purity≥90% by HPLC
Physicochemical Information
Cell permeableN
Peptide SequenceGlu-Val-Asn-Leu-Ψ-Ala-Ala-Glu-Phe [Ψ denotes replacement of CONH by (S)-CH(OH)CH₂]
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Protect from Moisture Protect from moisture
Do not freeze Ok to freeze
Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C). Avoid freeze/thaw cycles of solutions.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
496000-250UG 04055977199826

Documentation

InSolution™ OM99-2 - CAS 314266-76-7 - Calbiochem MSDS

Title

Safety Data Sheet (SDS) 

InSolution™ OM99-2 - CAS 314266-76-7 - Calbiochem Certificates of Analysis

TitleLot Number
496000

References

Reference overview
Ghosh, A.K., et al. 2001. J. Med. Chem. 44, 2865.
Turner III, R.T., et al. 2001. Biochemistry 40, 10001.
Ghosh, A.K., et al. 2000. J. Am. Chem. Soc. 122, 3522.
Hong, L., et al. 2000. Science 290,150.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision13-August-2008 RFH
SynonymsEVNLΨAAEF
DescriptionA peptidomimetic, highly potent, tight-binding transition-state analog inhibitor of human brain β-secretase (Ki = 1.6 nM, recombinant memapsin-2; Ki = 9.58 nM, recombinant pro-memapsin 2). Designed from the template of the β-secretase site of Swedish β-amyloid precursor protein (APP) with Asp to Ala replacement. Includes a nonhydrolyzable hydroxyethylene isostere between Leu and Ala. Also reported to inhibit cathepsin D at higher levels (Ki = 48 nM).
FormLiquid
FormulationA 1 mM (250µg in 280 µl) solution in DMSO. Supplied as a trifluoroacetate salt.
Intert gas (Yes/No) Packaged under inert gas
CAS number314266-76-7
Chemical formulaC₄₁H₆₄N₈O₁₄
Peptide SequenceGlu-Val-Asn-Leu-Ψ-Ala-Ala-Glu-Phe [Ψ denotes replacement of CONH by (S)-CH(OH)CH₂]
Structure formulaStructure formula
Purity≥90% by HPLC
Storage Protect from moisture
Protect from light
-20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C). Avoid freeze/thaw cycles of solutions.
Toxicity Standard Handling
ReferencesGhosh, A.K., et al. 2001. J. Med. Chem. 44, 2865.
Turner III, R.T., et al. 2001. Biochemistry 40, 10001.
Ghosh, A.K., et al. 2000. J. Am. Chem. Soc. 122, 3522.
Hong, L., et al. 2000. Science 290,150.