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506073 InSolution™ Glutaminase Inhibitor, Compound 968 - Calbiochem

InSolution™ Glutaminase Inhibitor, Compound 968 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: GAC Inhibitor, GLS1 Inhibitor I, KGA Inhibitor I, Kidney-Type Glutaminase Inhibitor I, 5-(3-Bromo-4-(dimethylamino)phenyl)-2,2-dimethyl-2,3,5,6-tetrahydrobenzo[a]phenanthridin-4(1H)-one

Primary Target: mitochondrial glutaminase
506073
Purchase on Sigma-Aldrich

Overview

Replacement Information

Key Spec Table

Empirical Formula
C₂₇H₂₇BrN₂O

Products

Catalogue NumberPackaging Qty/Pack
5.06073.0001 Sklená flaša 5 mg
Description
OverviewA cell-permeable benzophenanthridinone compound that acts as an allosteric and reversible inhibitor of mitochondrial glutaminase activity and represses the growth and invasive activity in glutaminase upregulated fibroblasts and in tumor cells (IC50 ≤ 10 µM in NIH3T3 cells stably expressing Dbl, Cdc42-F28L, Rac-F28L or RhoC-F30L mutants and in SKBR3 and MDA-MB231 cancer cells). Shown to effectively shrink tumor size in P-493 B xenografted mouse model (200 µg per inj. i.p., 12 days).
Catalogue Number506073
Brand Family Calbiochem®
SynonymsGAC Inhibitor, GLS1 Inhibitor I, KGA Inhibitor I, Kidney-Type Glutaminase Inhibitor I, 5-(3-Bromo-4-(dimethylamino)phenyl)-2,2-dimethyl-2,3,5,6-tetrahydrobenzo[a]phenanthridin-4(1H)-one
References
ReferencesWang, J.B., et al. 2010. Cancer Cell 18, 207.
Product Information
FormLiquid
FormulationA 10 mM (5 mg/1.05 ml) sterile-filtered solution of Glutaminase Inhibitor, Compound 968 (Cat. No. 352010) in DMSO.
Hill FormulaC₂₇H₂₇BrN₂O
Chemical formulaC₂₇H₂₇BrN₂O
Hygroscopic Hygroscopic
ReversibleY
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary Targetmitochondrial glutaminase
Purity≥99% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Dry Ice Only
Toxicity Standard Handling
Storage ≤ -70°C
Protect from Light Protect from light
Hygroscopic Hygroscopic
Avoid freeze/thaw Avoid freeze/thaw
Do not freeze Ok to freeze
Special InstructionsFollowing initial thaw slight warming may be required to resolubilize. Aliquot and freeze (-20°C). Aliquots are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
5.06073.0001 04055977243062

Documentation

InSolution™ Glutaminase Inhibitor, Compound 968 - Calbiochem MSDS

Title

Safety Data Sheet (SDS) 

InSolution™ Glutaminase Inhibitor, Compound 968 - Calbiochem Certificates of Analysis

TitleLot Number
506073

References

Reference overview
Wang, J.B., et al. 2010. Cancer Cell 18, 207.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision13-December-2013 JSW
SynonymsGAC Inhibitor, GLS1 Inhibitor I, KGA Inhibitor I, Kidney-Type Glutaminase Inhibitor I, 5-(3-Bromo-4-(dimethylamino)phenyl)-2,2-dimethyl-2,3,5,6-tetrahydrobenzo[a]phenanthridin-4(1H)-one
DescriptionA cell-permeable benzophenanthridinone compound that acts as an allosteric and reversible inhibitor of mitochondrial glutaminase activity and represses the growth and invasive activity in glutaminase upregulated fibroblasts and in tumor cells (IC50 ≤ 10 µM in NIH3T3 cells stably expressing Dbl, Cdc42-F28L, Rac-F28L or RhoC-F30L mutants and in SKBR3 and MDA-MB231 cancer cells). Shown to effectively shrink tumor size in P-493 B xenografted mouse model (200 µg per inj. i.p., 12 days).
FormLiquid
FormulationA 10 mM (5 mg/1.05 ml) sterile-filtered solution of Glutaminase Inhibitor, Compound 968 (Cat. No. 352010) in DMSO.
Intert gas (Yes/No) Packaged under inert gas
Chemical formulaC₂₇H₂₇BrN₂O
Structure formulaStructure formula
Purity≥99% by HPLC
Storage Protect from light
Avoid freeze/thaw
≤ -70°C
Hygroscopic
Do Not Freeze Ok to freeze
Special InstructionsFollowing initial thaw slight warming may be required to resolubilize. Aliquot and freeze (-20°C). Aliquots are stable for up to 6 months at -20°C.
Toxicity Standard Handling
ReferencesWang, J.B., et al. 2010. Cancer Cell 18, 207.