171264 Sigma-AldrichInSolution™ AMPK Inhibitor, Compound C•2HCl - CAS 866405-64-3 - Calbiochem
The InSolution™ AMPK Inhibitor, Compound C•2HCl, also referenced under CAS 866405-64-3, controls the biological activity of AMPK. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
More>> The InSolution™ AMPK Inhibitor, Compound C•2HCl, also referenced under CAS 866405-64-3, controls the biological activity of AMPK. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications. Less<<InSolution™ AMPK Inhibitor, Compound C•2HCl - CAS 866405-64-3 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Synonyms: AMPK Inhibitor I, 6-(4-(2-Piperidin-1-yl-ethoxy)-phenyl)-3-pyridin-4-ylpyrazolo[1,5-a]pyrimidine, 2HCl, H₂O, Compound C, 2HCl, H₂O
Recommended Products
Overview
| Replacement Information |
|---|
Key Spec Table
| CAS # | Empirical Formula |
|---|---|
| 866405-64-3 | C₂₄H₂₅N₅O |
Products
| Catalogue Number | Packaging | Qty/Pack | |
|---|---|---|---|
| 171264-2MG | Sklená flaša | 2 mg |
| Description | |
|---|---|
| Overview | A cell-permeable pyrrazolopyrimidine compound that acts as a potent, selective, reversible, and ATP-competitive inhibitor of AMPK (AMP-activated protein kinase; Ki = 109 nM in the presence of 5 µM ATP and the absence of AMP). Does not affect the activities of ZAPK, Syk, PKCθ, PKA, or JAK3. Blocks celluar activities induced by AICAr (Cat. No. 123040) or Metformin (Cat. No. 317240). Induces weight loss by attenuating AMPK-mediated food intake in mice. The solid form of this compound (Cat. No. 171260) is also available. |
| Catalogue Number | 171264 |
| Brand Family | Calbiochem® |
| Synonyms | AMPK Inhibitor I, 6-(4-(2-Piperidin-1-yl-ethoxy)-phenyl)-3-pyridin-4-ylpyrazolo[1,5-a]pyrimidine, 2HCl, H₂O, Compound C, 2HCl, H₂O |
| Product Information | |
|---|---|
| CAS number | 866405-64-3 |
| Form | Liquid |
| Formulation | A 10 mM (2 mg/408 µl) solution of AMPK Inhibitor, Compound C, 2HCl, (Cat. No. 171260) in H₂O. |
| Hill Formula | C₂₄H₂₅N₅O |
| Chemical formula | C₂₄H₂₅N₅O |
| Structure formula Image | |
| Quality Level | MQ100 |
| Applications |
|---|
| Biological Information | |
|---|---|
| Purity | ≥98% by HPLC |
| Physicochemical Information |
|---|
| Dimensions |
|---|
| Materials Information |
|---|
| Toxicological Information |
|---|
| Safety Information according to GHS |
|---|
| Safety Information |
|---|
| Product Usage Statements |
|---|
| Packaging Information | |
|---|---|
| Packaged under inert gas | Packaged under inert gas |
| Transport Information |
|---|
| Supplemental Information |
|---|
| Specifications |
|---|
| Global Trade Item Number | |
|---|---|
| Catalogue Number | GTIN |
| 171264-2MG | 04055977207200 |
Documentation
InSolution™ AMPK Inhibitor, Compound C•2HCl - CAS 866405-64-3 - Calbiochem MSDS
| Title |
|---|
InSolution™ AMPK Inhibitor, Compound C•2HCl - CAS 866405-64-3 - Calbiochem Certificates of Analysis
| Title | Lot Number |
|---|---|
| 171264 |
References
| Reference overview |
|---|
| Yu, P.B., et al. 2008. Nat. Chem. Biol 4, 33. Kim, E.K., et al. 2004. J. Biol. Chem. 279, 19970. Lee, M., et al. 2003. J. Biol. Chem. 278, 39653. Inoki, K., et al. 2003. Cell 115, 577. Fryer, L.G., 2002. FEBS Lett. 531, 189. Zhou, G., et al. 2001. J. Clin. Invest. 108, 1167. |
Brochure
| Title |
|---|
| New Products: Volume 3, 2012 |
| Data Sheet | ||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
|